Aggregation of cancer in first-degree relatives of patients with glioma
Aggregation of cancer in first-degree relatives of patients with glioma
复制标题
DOI：
10.1158/1055-9965.epi-07-0576
复制
发表时间：
2007-11-01
影响因子：
3.8
通讯作者：
Bondy, Melissa L.
中科院分区：
文献类型：
--
作者：
Scheurer, Michael E.;Etzel, Carol J.;Bondy, Melissa L.
背景：以往的研究对胶质瘤患者近亲不同肿瘤部位的风险评估尚无定论，然而恶性黑色素瘤一直被描述。方法：我们获得了1992年6月至2006年6月在M.D.Anderson癌症中心登记的1,476名75岁以下胶质瘤患者的家族史信息。将8746名一级亲属(FDR)中观察到的癌症数量(N=1,001)与来自监测、流行病学和最终结果计划的年龄、性别和日历年特定比率的预期数量进行比较，使用标准化发病率比(SIR)。结果：任何癌症的总体SIR为1.21(95%可信区间，1.14-1.29)。在45岁以下的富国富豪中，总体SIR为5.08，对于45岁以下的亲属，总体SIR为0.95。脑瘤(2.14)、黑色素瘤(2.02)和肉瘤(3.83)的SIRS显著升高。我们观察到过量的胰腺癌，这只在母亲中显著增加。结论：我们观察到在胶质瘤患者的FDR中，包括脑瘤和黑色素瘤的过量病例，癌症的总体发病率增加了21%，这可能表明这两种恶性肿瘤的基因贡献相似。一项大型的国际连锁研究正在进行中，以检查对家族性胶质瘤重要的潜在基因组区域。
Background: Previous studies have been inconclusive in estimating the risk of different cancer sites among close relatives of glioma patients; however, malignant melanoma has consistently been described.Methods: We obtained family history information from 1,476 glioma patients under age 75 years who registered at M. D. Anderson Cancer Center between June 1992 and June 2006. The number of observed cancers (N = 1,001) among 8,746 first-degree relatives (FDR) was compared with the number expected from age-, sex-, and calendar year-specific rates from the Surveillance, Epidemiology, and End Results Program using standardized incidence ratios (SIR).Results: The overall SIR for any cancer was 1.21 (95% confidence interval, 1.14-1.29). Among FDRs under 45 years the overall SIR was 5.08, and for relatives >45 years the overall SIR was 0.95. The SIRs were significantly elevated for brain tumors (2.14), melanoma (2.02), and sarcoma (3.83). We observed an excess of pancreatic cancer, which was significantly higher only among mothers.Conclusion: We observed an overall 21% increase in cancer among the FDRs of glioma patients including excess cases of brain tumors and melanoma, which could point to similar genetic contributions to these two malignancies. A large international linkage study is under way to examine potential genomic regions important for familial glioma.