Synthesis of (±)-sordaricin
Synthesis of (±)-sordaricin
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DOI：
10.1246/cl.2004.942
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发表时间：
2004-07-05
影响因子：
1.6
通讯作者：
Narasaka, K
中科院分区：
文献类型：
--
作者：
Kitamura, M;Chiba, S;Narasaka, K
以双环[5.3.0]癸-3-酮衍生物为原料，合成了抗真菌索达菌素的糖苷配基（+/-）-索达菌素。通过钯催化的分子内Tsuji-Trost反应构建了索达菌素的双环[2.2.1]庚烯骨架。
(+/-)-Sordaricin, the aglycon of antifungal sordarin, was synthesized starting from bicyclo[5.3.0]decan-3-one derivative. The strained bicyclo[2.2.1]heptene framework of sordaricin was constructed by the palladium-catalyzed intramolecular Tsuji-Trost reaction.