Elevated systemic concentrations of soluble ICAM-1 (sICAM) are not reflected in the gingival crevicular fluid of smokers with periodontitis
Elevated systemic concentrations of soluble ICAM-1 (sICAM) are not reflected in the gingival crevicular fluid of smokers with periodontitis
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DOI：
10.1177/00220345010800070901
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发表时间：
2001-07-01
影响因子：
7.6
通讯作者：
Scott, DA
中科院分区：
文献类型：
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作者：
Fraser, HS;Palmer, RM;Scott, DA
吸烟者血清可溶性细胞间粘附分子-1（sICAM-1）水平升高可能对牙周炎有免疫调节作用。本研究的目的是比较吸烟者和非吸烟者牙周病患者血清龈沟液（GCF）中sICAM-1的浓度。采用酶联免疫吸附法（ELISA）检测14例年龄、性别匹配的吸烟者和14例非吸烟者牙周炎患者血清和龈沟液中sICAM-1的含量。吸烟者的平均血清sICAM-1浓度（331 ng mL-1）显著高于非吸烟者（238 ng mL-1，p = 0.008）。然而，吸烟者GCF中sICAM-1的浓度（83 ng mL-1）显著低于非吸烟者（212 ng mL-1，p = 0.013）。GCF中sICAM-1浓度与血清中sICAM-1浓度的差异仅在吸烟组有显著性意义（P < 0.001）。由于GCF是一种血清来源的组织渗出物，这些结果表明，在吸烟者中，循环sICAM-1分子在其从牙周微血管系统或牙周组织内通过时受到影响。
Raised serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in smokers could have immunomodulatory effects in periodontitis. The aim of this study was to compare serum gingival crevicular fluid (GCF) concentrations of sICAM-1 in smokers and non-smokers with periodontal disease. sICAM-1 in serum and GCF collected from age- and gender-matched smokers (n = 14) and non-smokers (n = 14) with periodontitis were measured by ELISA. Mean serum sICAM-1 concentrations were significantly elevated in smokers (331 ng mL(-1)), compared with non-smokers (238 ng mL(-1), p = 0.008). However, the concentration of sICAM-1 in the GCF was significantly lower in the smokers (83 ng mL(-1)), compared with non-smokers (212 ng mL(-1), p = 0.013). The difference between concentrations of sICAM-1 in GCF and serum was significant only I in smokers (p < 0.001). Since GCF is a serum-derived tissue exudate, these results suggest that, in smokers, circulating sICAM-1 molecules are affected either in their passage from the periodontal microvasculature or within the periodontal tissues.