Alterations of default mode and cingulo-opercular salience network and frontostriatal circuit: A candidate endophenotype of obsessive-compulsive disorder
Alterations of default mode and cingulo-opercular salience network and frontostriatal circuit: A candidate endophenotype of obsessive-compulsive disorder
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DOI：
10.1016/j.pnpbp.2022.110516
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发表时间：
2022-01
影响因子：
5.6
通讯作者：
Hirofumi Tomiyama;Keitaro Murayama;K. Nemoto;Suguru Hasuzawa;Taro Mizobe;Kenta Kato;Akira Matsuo
中科院分区：
文献类型：
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作者：
Hirofumi Tomiyama;Keitaro Murayama;K. Nemoto;Suguru Hasuzawa;Taro Mizobe;Kenta Kato;Akira Matsuo
研究背景强迫症（OCD）患者存在异常的静息态大规模扣带-鳃盖突出（SN）、默认模式（DMN）和前顶叶网络（FPN）的内在网络。然而，它仍然是未知的，是否未受影响的一级亲属的强迫症患者有这些变化作为一个脆弱性标记的disorder.MethodsWe进行了静息状态功能磁共振成像（rsfMRI）扫描47例无药物强迫症患者，21例未受影响的健康的一级亲属的强迫症患者，和62名健康对照（HC）参与者。我们从SN中探索了三组之间功能连接的差异（种子：前扣带皮层（AI）和背侧前扣带皮层（dACC）），DMN（种子：内侧前额叶皮层（MPFC）和后顶叶皮层（PCC）），以及FPN（种子：背外侧前额叶皮层（DLPFC））。结果与HC相比，强迫症患者和一级亲属在AI和PCC之间以及DLPFC和丘脑之间显示出显著更大的功能连接。与一级亲属和HC相比，OCD患者表现出PCC和DLPFC之间的功能连接减少，这种改变的功能连接与OCD组内的焦虑和抑郁症状呈负相关。我们的研究结果表明，大规模的内在网络之间的变化和背侧认知皮质-纹状体-丘脑-皮质（CSTC）电路可以代表内表型标记的强迫症。
BackgroundIt is gradually becoming clear that obsessive-compulsive disorder (OCD) patients have aberrant resting-state large-scale intrinsic networks of cingulo-opercular salience (SN), default mode (DMN), and front-parietal network (FPN). However, it remains unknown whether unaffected first-degree relatives of OCD patients have these alterations as a vulnerability marker to the disorder.MethodsWe performed resting-state functional magnetic resonance imaging (rsfMRI) scans of 47 medication-free OCD patients, 21 unaffected healthy first-degree relatives of OCD patients, and 62 healthy control (HC) participants. We explored differences between the three groups in the functional connectivity from SN (seeds: anterior-insula (AI) and dorsal anterior cingulate cortex (dACC)), DMN (seeds: medial prefrontal cortex (MPFC) and posterior parietal cortex (PCC)), and FPN (seeds: dorsolateral prefrontal cortex (DLPFC)).ResultsCompared to HC, both OCD patients and first-degree relatives showed significantly greater functional connectivity between AI and PCC and between DLPFC and the thalamus. Compared to first-degree relatives and HC, OCD patients showed reduced functional connectivity between PCC and DLPFC, and this altered functional connectivity was negatively correlated with anxiety and depressive symptom within OCD group.ConclusionsOCD patients and unaffected first-degree relatives of OCD patients showed overlapping alterations in resting state functional connectivity between the regions of SN and DMN and between DLPFC and the thalamus. Our results suggested that alterations between large-scale intrinsic networks and within the dorsal cognitive cortico-striato-thalamo-cortical (CSTC) circuit could represent endophenotype markers of OCD.