Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis
Efforts toward rapid construction of the cortistatin A carbocyclic core via enyne-ene metathesis
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DOI：
10.1039/c004275g
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发表时间：
2010-01-01
影响因子：
3.2
通讯作者：
Stoltz, Brian M.
中科院分区：
文献类型：
--
作者：
Baumgartner, Corinne;Ma, Sandy;Stoltz, Brian M.
公开了我们通过烯-烯复分解构建皮质激素A碳环核心的努力。有趣的是，在我们的五元D-环片段中尝试的仲甲磺酸酯的S（N）2反转得到保留立体化学的产物。
Our efforts toward the construction of the carbocylic core of cortistatin A via an enyne-ene metathesis are disclosed. Interestingly, an attempted S(N)2 inversion of a secondary mesylate in our five-membered D-ring piece gave a product with retention of stereochemistry.