Asymmetric Photocatalysis Enabled by Chiral Organocatalysts.
Asymmetric Photocatalysis Enabled by Chiral Organocatalysts.
复制标题
手性有机催化剂实现的不对称光催化。
DOI：
10.1002/cctc.202101292
复制
发表时间：
2022
期刊：
影响因子：
4.5
通讯作者：
Ngai,Ming-Yu
中科院分区：
文献类型：
--
作者：
Yao,Wang;Bergamino,EmmanuelABazan;Ngai,Ming-Yu
可见光催化已成为有机合成中的一种多功能工具。然而，由于不需要的光化学背景反应以及在光催化条件下产生的高活性自由基或自由基离子中间体的参与，在光催化反应中实现精确的立体控制一直是一个长期的挑战。为了解决这一问题并扩大光催化反应的合成应用，最近出现了许多创新的策略，包括单催化和双催化方法。其中，利用烯胺催化、金属离子催化、Brnsted酸碱催化、杂环卡宾催化等手性有机催化方法诱导光催化反应的手性转移已被广泛探索。这篇综述旨在提供手性有机催化剂实现的不对称光催化反应的最新、全面的概述，该综述将于2021年6月出版。讨论了每种反应的底物范围、优点、局限性和提出的反应机理。该综述可为可见光诱导不对称光催化的发展提供参考，促进这些反应的化学反应活性和立体选择性的提高。
Visible‐light photocatalysis has advanced as a versatile tool in organic synthesis. However, attaining precise stereocontrol in photocatalytic reactions has been a longstanding challenge due to undesired photochemical background reactions and the involvement of highly reactive radicals or radical ion intermediates generated under photocatalytic conditions. To address this problem and expand the synthetic utility of photocatalytic reactions, a number of innovative strategies, including mono‐ and dual‐catalytic approaches, have recently emerged. Of these, exploiting chiral organocatalysis, such as enamine catalysis, iminium‐ion catalysis, Brønsted acid/base catalysis, andN‐heterocyclic carbene catalysis, to induce chirality transfer of photocatalytic reactions has been widely explored. This Review aims to provide a current, comprehensive overview of asymmetric photocatalytic reactions enabled by chiral organocatalysts published through June 2021. The substrate scope, advantages, limitations, and proposed reaction mechanisms of each reaction are discussed. This review should serve as a reference for the development of visible‐light‐induced asymmetric photocatalysis and promote the improvement of the chemical reactivity and stereoselectivity of these reactions.