Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival.
Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival.
复制标题
DOI：
10.1038/bjc.1995.30
复制
发表时间：
1995-01
影响因子：
8.8
通讯作者：
Ellis, I O
中科院分区：
文献类型：
--
作者：
Pinder, S E;Wencyk, P;Sibbering, D M;Bell, J A;Elston, C W;Nicholson, R;Robertson, J F;Blamey, R W;Ellis, I O
现在可以通过微波抗原修复技术，使用单克隆抗体MIB1在组织的石蜡切片上评估肿瘤的“生长分数”。使用CAS 200图像分析仪对177例原发性可手术乳腺癌患者的肿瘤进行了MIB1标记指数研究，这些患者的长期随访数据已知。统计学分析显示MIB1标记指数与组织学分级（P < 0.001）、肿瘤大小（P = 0.002）、肿瘤类型（P < 0.001）以及患者存活率（P < 0.001）之间存在强相关性。在该组患者中，未发现与淋巴结分期（P = 0.974）或区域复发（P = 0.185）、有无远处转移（P = 0.418）、患者年龄（P = 0.309）、绝经状态（P = 0.181）或雌激素受体状态（P = 0.401）相关。在生存的多变量分析中，当包括组织学分级、淋巴结分期和肿瘤大小以及MIB1标记指数时，发现每一个都具有独立的意义。如果不包括组织学分级，则MIB1替代其作为预测该组患者生存率的最重要变量。结果表明，肿瘤生长分数，评估的MIB1标记指数，是一个重要的预测生存。
The 'growth fraction' of tumours can now be assessed on paraffin sections of tissues using the monoclonal antibody MIB1 by a microwave antigen retrieval technique. The MIB1 labelling index was studied using a CAS 200 image analyser in 177 tumours from women with primary operable breast carcinoma in whom long-term follow-up data were known. Statistical analysis showed a strong association between the MIB1 labelling index and histological grade (P < 0.001), tumour size (P = 0.002), tumour type (P < 0.001) and also patient survival (P < 0.001). No association with lymph node stage (P = 0.974) or regional recurrence (P = 0.185), the presence or absence of distant metastases (P = 0.418), patient age (P = 0.309), menopausal status (P = 0.181) or oestrogen receptor status (P = 0.401) was found in this group of patients. In multivariate analysis for survival, when histological grade, lymph node stage and tumour size were included as well as the MIB1 labelling index, each was found to be of independent significance. If histological grade was not included, MIB1 replaced it as the most important variable predicting for survival in this group of patients. The results suggest that the tumour growth fraction, as assessed by the MIB1 labelling index, is an important predictor of survival.