HIGH URIC-ACID AS AN INDICATOR OF CARDIOVASCULAR-DISEASE - INDEPENDENCE FROM OBESITY
HIGH URIC-ACID AS AN INDICATOR OF CARDIOVASCULAR-DISEASE - INDEPENDENCE FROM OBESITY
复制标题
DOI：
10.1016/0002-9343(80)90111-4
复制
发表时间：
1980-01-01
影响因子：
5.9
通讯作者：
FESSEL, WJ
中科院分区：
文献类型：
--
作者：
FESSEL, WJ
在3组患者中，研究了体重不是高尿酸血症和心血管疾病之间关系的潜在因素的假设。在111例无症状高尿酸血症受试者中，6名患者出现动脉粥样硬化性心脏病;他们的平均体重为77.4 kg（172磅），而其余患者为79.7 kg（177磅）; 111名患者中有25名患者出现高血压;他们的平均体重并不明显高于其余患者。在156例确诊痛风的患者中，随访133个月，平均95个月后，25例患者出现临床动脉粥样硬化;他们的平均体重为78.3kg（174磅），而其余81名患者的平均体重为79.7kg（177磅），这些患者的记录体重在75 ± 100磅范围内。12个月时在他们痛风发作后在1967年有血尿酸记录的1356名60-69岁男性中，当死亡按血尿酸水平排列时，随后死于心血管疾病的人数呈阶梯式增加，而当死亡按体重排列时则无此趋势。高尿酸血症预测未来心血管疾病与体重无关。
In 3 groups of patients, the hypothesis that body weight is not the factor underlying the relation between hyperuricemia and cardiovascular disease was investigated. Among 111 subjects with asymptomatic hyperuricemia followed for 108 mo., atherosclerotic heart disease developed in 6; their mean weight was 77.4 kg (172 lb) compared with 79.7 kg (177 lb) in the remainder; in 25 of the 111 patients hypertension developed; their mean weight was not significantly higher than that of the remainder. Among 156 patients with established gout followed for 133 mo., clinical atherosclerosis developed in 25 after a mean of 95 mo.; their mean weight was 78.3 kg (174 lb) contrasted with 79.7 kg (177 lb) in those 81 of the remaining patients who had a weight recorded within 75 .+-. 12 mo. after their initial attack of gout. Among 1356 men aged 60-69 yr who had their serum uric acid recorded in 1967, subsequent deaths from cardiovascular disease showed a stepwise increase when deaths were arranged according to the serum uric acid levels but not when they were arranged according to body weight. Hyperuricemia predicts future cardiovascular diseae independently of body weight.