Biomembrane‐Functionalized Micromotors: Biocompatible Active Devices for Diverse Biomedical Applications
Biomembrane‐Functionalized Micromotors: Biocompatible Active Devices for Diverse Biomedical Applications
复制标题
生物膜——功能化微电机：用于多种生物医学应用的生物相容性有源器件
DOI：
10.1002/adma.202107177
复制
发表时间：
2021
影响因子：
29.4
通讯作者：
Wang, Joseph
中科院分区：
文献类型：
--
作者：
Zhang, Fangyu;Mundaca‐Uribe, Rodolfo;Askarinam, Nelly;Li, Zhengxing;Gao, Weiwei;Zhang, Liangfang;Wang, Joseph
有相当大的兴趣，在开发合成微电机的生物功能，多功能和适应能力的生物医学应用。从这个角度来看，细胞膜功能化微电机成为一个有吸引力的平台。这种新型微电机在复杂的生物环境中表现出增强的推进力和令人信服的性能，使其适用于各种体内应用，包括药物输送，解毒，免疫调节和光疗。本文综述了基于这些领域不同微电机设计和细胞膜涂层的各种概念验证研究。该综述侧重于电机结构和性能的关系，并强调了细胞膜功能化如何克服传统合成微电机所面临的障碍，同时赋予它们独特的能力。总的来说，细胞膜功能化微电机有望推进微电机研究，并促进其向实际应用的转化。
There has been considerable interest in developing synthetic micromotors with biofunctional, versatile, and adaptive capabilities for biomedical applications. In this perspective, cell membrane‐functionalized micromotors emerge as an attractive platform. This new class of micromotors demonstrates enhanced propulsion and compelling performance in complex biological environments, making them suitable for various in vivo applications, including drug delivery, detoxification, immune modulation, and phototherapy. This article reviews various proof‐of‐concept studies based on different micromotor designs and cell membrane coatings in these areas. The review focuses on the motor structure and performance relationship and highlights how cell membrane functionalization overcomes the obstacles faced by traditional synthetic micromotors while imparting them with unique capabilities. Overall, the cell membrane‐functionalized micromotors are expected to advance micromotor research and facilitate its translation towards practical uses.