Complex hair cycle domain patterns and regenerative hair waves in living rodents
Complex hair cycle domain patterns and regenerative hair waves in living rodents
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DOI：
10.1038/sj.jid.5701180
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发表时间：
2008-05-01
影响因子：
6.5
通讯作者：
Chuong, Cheng-Ming
中科院分区：
文献类型：
--
作者：
Plikus, Maksim V.;Chuong, Cheng-Ming
单个毛囊经历再生和退化周期。在一个群体中，毛囊可能会在生长期重新进入期间相互影响，从而形成传播再生的毛发波浪。我们回顾了这些再生的头发波和复杂的头发周期域，这是最近报道的转基因小鼠。描述了两种追踪体内大量毛囊中传播的发波的非侵入性方法。我们还回顾了古典文献中关于“毛发生长模式”的早期描述。我们破译的“行为规则”，决定如何动态的头发波浪导致复杂的头发周期域。一般来说，当再生发波到达响应区域时，单个域扩展，并且当波到达非响应区域时，边界形成。随着小鼠年龄的增长，多个毛发周期域形成，每个都有自己的再生节奏。域模式可以被生理事件重置，如怀孕和哺乳。纵向截面显示毛囊阵列在一个连续的头发周期阶段。毛周期结构域不同于区域特异性结构域。再生的头发波浪不同于新形成的毛囊的发育波浪。这项研究为成人皮肤的动态和器官再生的生理调节提供了见解。
Single hair follicles go through regeneration and involution cycles. In a population, hair follicles may affect each other during anagen re-entry, thus forming propagating regenerative hair waves. We review these regenerative hair waves and complex hair cycle domains, which were recently reported in transgenic mice. Two non-invasive methods to track the propagating hair wave in large populations of hair follicles in vivo are described. We also reviewed early accounts of "hair growth patterns" from classical literature. We decipher the "behavior rules" that dictate how dynamic hair waves lead to complex hair cycle domains. In general, a single domain expands when a regenerative hair wave reaches a responsive region and boundaries form when the wave reaches a nonresponsive region. As mice age, multiple hair cycle domains form, each with its own regeneration rhythm. Domain patterns can be reset by physiological events such as pregnancy and lactation. Longitudinal sections across domains show arrays of follicles in a continuum of hair cycle stages. Hair cycle domains are different from regional specificity domains. Regenerative hair waves are different from the developmental wave of newly forming hair follicles. The study provides insights into the dynamic states of adult skin and physiological regulation of organ regeneration.