Altered uric acid levels and disease states
Altered uric acid levels and disease states
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DOI：
10.1124/jpet.107.129031
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发表时间：
2008-01-01
影响因子：
3.5
通讯作者：
Firestein, Bonnie L.
中科院分区：
文献类型：
--
作者：
Kutzing, Melinda K.;Firestein, Bonnie L.
血尿酸浓度的变化，无论是高于或低于正常水平，都与许多疾病状态有关。异常高的尿酸水平与痛风、高血压、心血管疾病和肾脏疾病相关，而尿酸浓度降低与多发性硬化症、帕金森病、阿尔茨海默病和视神经炎有关。从历史上看，尿酸一直被认为是这些疾病状态的标志。然而，最近的研究提供了证据，表明尿酸实际上可能在此类疾病的发展或进展中发挥作用。因此，操纵尿酸浓度现在要么被包括在各种疾病的治疗中，要么被研究用于治疗各种疾病状态。
Altered serum uric acid concentrations, both above and below normal levels, have been linked to a number of disease states. An abnormally high uric acid level has been correlated with gout, hypertension, cardiovascular disease, and renal disease, whereas a reduced uric acid concentration has been linked to multiple sclerosis, Parkinson's disease, Alzheimer's disease, and optic neuritis. Historically, uric acid has been considered a marker of these disease states. Recent studies, however, have provided evidence that uric acid may actually play a role in the development or progression of such diseases. As a result, the manipulation of uric acid concentrations is now either included in, or being investigated for, the treatment of a variety of disease states.