Mycoplasma Genitalium and Mycoplasma Hominis are prevalent and correlated with HIV risk in MSM: a cross-sectional study in Shenyang, China
Mycoplasma Genitalium and Mycoplasma Hominis are prevalent and correlated with HIV risk in MSM: a cross-sectional study in Shenyang, China
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生殖支原体和人型支原体在 MSM 中普遍存在并与 HIV 风险相关：中国沉阳的一项横断面研究
DOI：
10.1186/s12879-019-4138-5
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发表时间：
2019-06-04
影响因子：
3.7
通讯作者：
Huang, De-Sheng
中科院分区：
文献类型：
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作者：
Zhao, Ning;Li, Katherine T.;Huang, De-Sheng
背景：很高比例的男男性行为者（MSM）使用地理社交网络应用程序（App）寻找伴侣。然而，应用程序使用与艾滋病毒风险的关系尚不清楚。此外，一些性传播感染（STIs）的风险，包括生殖支原体，很少被研究的MSM。方法：MSM在以社区为基础的HIV检测点，中国沈阳，被招募。完成问卷调查后，采集直肠拭子和静脉血标本。然后，我们使用多重PCR同时检测了10种STI（沙眼衣原体[CT]、淋病奈瑟菌[NG]、解脲脲原体[Uu]、微小脲原体[Up 1、Up3、Up 6、Up 14）、人型支原体[Mh]、生殖支原体[Mg]和单纯疱疹病毒2型（HSV-2）。我们还进行了血液检测HIV，梅毒，丙型肝炎抗体（HCV-Ab），乙肝B表面抗原（HBsAg），甲型肝炎IgM（HAV-IgM）等。结果：183名MSM参与了这项研究，其中51.4%的报告在过去的一年中通过应用程序寻求合作伙伴。HIV感染率为19.7%，梅毒感染率为12.0%，甲肝感染率为1.1%，直肠支原体感染率为15.3%，Mh感染率为7.1%。多因素Logistic回归分析显示，HIV感染与APP使用行为（aOR = 2.6）、Mg感染（aOR = 3.2）、Mh感染（aOR = 4.1）和Syphilis感染（aOR = 3.1）独立相关（均P < 0.05）。应利用地理社交网络应用程序进行针对MSM的艾滋病毒干预。有必要进行更广泛的性传播感染筛查，特别是对男男性行为者中的Mg、Mh和Sylgene进行筛查。
Background:A high proportion of men who have sex with men (MSM) use geosocial networking apps (Apps) to seek partners. However, the relationship of app use with HIV risk is unknown. Further, the risks of some sexually transmitted infection (STIs), including Mycoplasma genitalium, have seldom been studied among MSM.Methods:MSM were enrolled at a community-based HIV testing site in Shenyang, China. After completing a questionnaire survey, we collected rectal swabs and venous blood specimens. We then simultaneously tested for ten STIs (Chlamydia trachomatis [CT], Neisseria gonorrhea [NG], Ureaplasma urealyticum [Uu], Ureaplasma parvum species [Up1, Up3, Up6, Up14), Mycoplasma hominis [Mh], Mycoplasma genitalium [Mg], and Herpes Simplex Virus Type 2 (HSV-2) using multiple PCR. We also performed blood tests for HIV, Syphilis, Hepatitis C antibody (HCV-Ab), Hepatitis B Surface Antigen (HBsAg), and Hepatitis A-IgM (HAV-IgM), etc. RESULTS: One hundred and eighty-three MSM participated in this study, of which 51.4% reported seeking partners through apps in the past year. The prevalence of HIV was 19.7%, Syphilis 12.0%, HAV 1.1%, rectal Mg 15.3% and Mh 7.1%. Multivariable logistic regression showed that HIV infection was independently correlated with app-using behavior (adjusted odds ratio[aOR] = 2.6), Mg infection (aOR = 3.2), Mh infection (aOR = 4.1) and Syphilis infection (aOR = 3.1) (each P < 0.05).Conclusions:App use, Mg, Mh and Syphilis infection were correlated with higher HIV Risk in MSM. Geosocial networking apps should be utilized for HIV interventions targeting MSM. There is a need for more expansive STIs screening, particularly for Mg, Mh and Syphilis in MSM.