Influences of motor speech impairments on the presentation of dysphagia in progressive supranuclear palsy.
Influences of motor speech impairments on the presentation of dysphagia in progressive supranuclear palsy.
复制标题
运动性言语障碍对进行性核上性麻痹吞咽困难表现的影响。
DOI：
10.1080/17549507.2023.2221407
复制
发表时间：
2024
影响因子：
1.8
通讯作者：
Josephs,KeithA
中科院分区：
文献类型：
--
作者：
Petroi-Bock,Diana;Clark,HeatherM;Stierwalt,JulieAG;Botha,Hugo;Ali,Farwa;Whitwell,JenniferL;Josephs,KeithA
目的本研究的目的是检查运动言语特征的差异是否与进行性核上性麻痹 (PSP) 中吞咽困难的表现相关，因为检查这种关系的数据很少。方法对 73 名 PSP 参与者的运动言语障碍 (MSD) 类型和严重程度以及特定吞咽变量进行分析，以获得这些关系的见解。结果结果显示，大多数参与者 (93%) 患有构音障碍，其中 19% 并发言语失用症（AOS）。 MSD 严重程度越高，咽相损伤越严重（95% CI [−0.917，−0.146]，p= 0.008）。虽然某些运动言语和吞咽评分在参与者之间差异很小，但当存在特定的 MSD 特征时，这些功能的增量变化更有可能发生。观察到患有痉挛性构音障碍和/或 AOS 的参与者表现出更严重的吞咽困难的趋势。结论本研究指出需要在 PSP 的护理标准中进行彻底的神经学评估，包括言语病理学咨询。对运动言语和吞咽功能的综合评估可以为鉴别诊断提供信息，并帮助患者/家庭在神经退行性疾病的情况下面临沟通和营养方式的决定。额外的研究可能会对 PSP 的相关评估和干预考虑因素产生更深入的见解。
PurposeThe purpose of this study was to examine whether differences in motor speech features are related to presentations of dysphagia in progressive supranuclear palsy (PSP) given the sparsity of data examining this relationship.MethodMotor speech disorder (MSD) type and severity along with specific swallowing variables were analysed to obtain insights among these relationships in 73 participants with PSP.ResultResults revealed that most participants (93%) had dysarthria, with 19% having co-occurring apraxia of speech (AOS). Greater MSD severity was related to more severe pharyngeal phase impairments (95% CI [−0.917, −0.146],p= 0.008). While certain motor speech and swallowing scores varied minimally across participants, incremental changes in these functions were more likely to occur when specific MSD features were present. A trend for participants with spastic dysarthria and/or AOS to exhibit more severe dysphagia was observed.ConclusionThis study points to the need for thorough neurological evaluation, with inclusion of speech-language pathology consultation, in the standard of care for PSP. Comprehensive assessment of both motor speech and swallowing functions can inform differential diagnosis and assist patients/families facing decisions regarding modalities for communication and nutrition in the setting of neurodegenerative disease. Additional research may yield greater insights about relevant assessment and intervention considerations in PSP.