Childhood abuse, parental warmth, and adult multisystem biological risk in the Coronary Artery Risk Development in Young Adults study
Childhood abuse, parental warmth, and adult multisystem biological risk in the Coronary Artery Risk Development in Young Adults study
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DOI：
10.1073/pnas.1315458110
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发表时间：
2013-10-15
影响因子：
11.1
通讯作者：
Seeman, Teresa E.
中科院分区：
文献类型：
--
作者：
Carroll, Judith E.;Gruenewald, Tara L.;Seeman, Teresa E.
儿童期虐待增加了成人发病和死亡的风险。不太清楚的是，这种“有毒”压力是如何在几十年后影响健康的，以及保护性因素是否会阻止这些影响。早期的生物嵌入被认为是通过对神经电路的编程来发生的，该神经电路影响对随后的压力的生理反应模式，导致多个调节系统的磨损。为了检验这一假设，我们将儿童期虐待的报告与一种全面的18个生物标记物的多系统风险测量相关联，并检查了慈爱的父母形象的存在是否缓冲了儿童期虐待对成年风险的影响。共有756名受试者(45.8%的白人，42.7%的男性)参与了青年冠状动脉风险发展研究的这项辅助性亚研究。童年压力是通过使用危险家庭问卷来确定的，这是一个经过良好验证的回溯性自我报告量表。调整了年龄、性别、种族、父母教育和口服避孕药使用的线性回归模型发现，儿童虐待报告与多系统健康风险之间存在显著的正相关关系[B(SE)=0.68(0.16)；P<；0.001]。相反，儿童时期报告的父母温暖和爱的程度越高，多系统健康风险越低[B(SE)=-0.4(0.14)；P<；0.005]。研究发现虐待和温暖之间存在显著的交互作用(P<；0.05)，报告童年时低水平的爱和情感而高水平的虐待的人在成年后具有最高的多系统风险。
Childhood abuse increases adult risk for morbidity and mortality. Less clear is how this "toxic" stress becomes embedded to influence health decades later, and whether protective factors guard against these effects. Early biological embedding is hypothesized to occur through programming of the neural circuitry that influences physiological response patterns to subsequent stress, causing wear and tear across multiple regulatory systems. To examine this hypothesis, we related reports of childhood abuse to a comprehensive 18-biomarker measure of multisystem risk and also examined whether presence of a loving parental figure buffers against the impact of childhood abuse on adult risk. A total of 756 subjects (45.8% white, 42.7% male) participated in this ancillary substudy of the Coronary Artery Risk Development in Young Adults Study. Childhood stress was determined by using the Risky Families Questionnaire, a well-validated retrospective self-report scale. Linear regression models adjusting for age, sex, race, parental education, and oral contraceptive use found a significant positive relationship between reports of childhood abuse and multisystem health risks [B (SE) = 0.68 (0.16); P < 0.001]. Inversely, higher amounts of reported parental warmth and affection during childhood was associated with lower multisystem health risks [B (SE) = -0.40 (0.14); P < 0.005]. A significant interaction of abuse and warmth (P < 0.05) was found, such that individuals reporting low levels of love and affection and high levels of abuse in childhood had the highest multisystem risk in adulthood.