Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications
Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications
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DOI：
10.1002/adma.201705013
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发表时间：
2018-04-05
影响因子：
29.4
通讯作者：
Grover, Liam M.
中科院分区：
文献类型：
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作者：
Cooke, Megan E.;Jones, Simon W.;Grover, Liam M.
用于临床的新材料的开发受到繁琐的监管框架的限制，这意味着将全新材料带入临床可能会使翻译在经济上不可行。解决这一问题的一种方法是构建已经获得监管机构批准的材料，使它们表现出非常独特的物理特性，并可用于更广泛的临床应用。在这里，重点是通过修改加工条件在多个长度尺度上对软材料进行结构化。通过对新形成的材料施加剪切，可以触发聚合物链的分子重组，使得它们聚集以形成颗粒和带状结构。然后这些结构在零剪切下弱相互作用，形成固体状材料。由此产生的自愈网络特别适用于一系列不同的生物医学应用。这些材料是如何被用来允许治疗实体（细胞和蛋白质）的交付，并作为一个更大规模的组织结构的增材层制造的支持进行了讨论。该技术能够开发一系列用于组织增强和再生的新型材料和结构。
The development of new materials for clinical use is limited by an onerous regulatory framework, which means that taking a completely new material into the clinic can make translation economically unfeasible. One way to get around this issue is to structure materials that are already approved by the regulator, such that they exhibit very distinct physical properties and can be used in a broader range of clinical applications. Here, the focus is on the structuring of soft materials at multiple length scales by modifying processing conditions. By applying shear to newly forming materials, it is possible to trigger molecular reorganization of polymer chains, such that they aggregate to form particles and ribbon-like structures. These structures then weakly interact at zero shear forming a solid-like material. The resulting self-healing network is of particular use for a range of different biomedical applications. How these materials are used to allow the delivery of therapeutic entities (cells and proteins) and as a support for additive layer manufacturing of larger-scale tissue constructs is discussed. This technology enables the development of a range of novel materials and structures for tissue augmentation and regeneration.