Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism
Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism
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DOI：
10.3945/ajcn.2008.26615
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发表时间：
2009-01-01
影响因子：
7.1
通讯作者：
Gaylor, David W.
中科院分区：
文献类型：
--
作者：
James, S. Jill;Melnyk, Stepan;Gaylor, David W.
背景：一些神经行为障碍的代谢异常和靶向治疗试验已被报道，但对自闭症的研究相对较少。目的：本研究的目的是确定代谢前体甲钴胺和叶酸治疗是否能改善自闭症儿童血浆转甲基化/硫化代谢物浓度和谷胱甘肽氧化还原状态。设计：在一项开放标签试验中，40名自闭症儿童接受75微克/公斤甲钴胺(2次/周)和400微克亚叶酸(2次/天)治疗3个月。检测治疗前后转甲基化/硫化途径中的代谢物，并与年龄匹配的对照组儿童进行比较。结果：自闭症儿童治疗前代谢物浓度与对照组儿童相比有显著差异。3个月干预组半胱氨酸、半胱氨酸甘氨酸和谷胱甘肽浓度显著升高(P
Background: Metabolic abnormalities and targeted treatment trials have been reported for several neurobehavioral disorders but are relatively understudied in autism.Objective: The objective of this study was to determine whether or not treatment with the metabolic precursors, methylcobalamin and folinic acid, would improve plasma concentrations of transmethylation/transsulfuration metabolites and glutathione redox status in autistic children.Design: In an open-label trial, 40 autistic children were treated with 75 mu g/kg methylcobalamin ( 2 times/wk) and 400 mu g folinic acid ( 2 times/d) for 3 mo. Metabolites in the transmethylation/transsulfuration pathway were measured before and after treatment and compared with values measured in age-matched control children.Results: The results indicated that pretreatment metabolite concentrations in autistic children were significantly different from values in the control children. The 3-mo intervention resulted in significant increases in cysteine, cysteinylglycine, and glutathione concentrations ( P