Association between childhood obesity and metabolic syndrome: evidence from a large sample of Chinese children and adolescents.
Association between childhood obesity and metabolic syndrome: evidence from a large sample of Chinese children and adolescents.
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DOI：
10.1371/journal.pone.0047380
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Mi J
中科院分区：
文献类型：
--
作者：
Chen F;Wang Y;Shan X;Cheng H;Hou D;Zhao X;Wang T;Zhao D;Mi J
在中国，关于儿童代谢综合征（MetS）的数据有限。我们的目的是评估MetS相关成分的患病率及其与肥胖的关系。数据收集作为对北京19593名6-18岁儿童met的代表性研究的一部分。一般肥胖以身体质量指数（BMI）评估，中心性肥胖以腰围评估。手指毛细血管血检查评估甘油三酯（TG）、总胆固醇（TC）和空腹血糖受损（IFG）。从3814名10-18岁儿童的亚样本中采集静脉血样进行met分类。MetS是根据国际糖尿病联合会2007年的定义定义的。利用logistic回归模型检验met相关成分与肥胖程度和类型之间的关联。超重、肥胖、高血压、TG、TC和IFG升高的患病率分别为13.6%、5.8%、8.5%、8.8%、1.2%和2.5%。与正常体重的儿童相比，超重和肥胖儿童更有可能出现其他与MetS相关的成分。在3814名10-18岁儿童的亚样本中，肥胖受试者的MetS患病率远高于正常体重的同龄人（27.6%比0.2%）。患有全身性和中枢性肥胖的儿童met患病率最高。与正常体重儿童相比，超重和肥胖儿童更容易发生MetS（超重：OR = 67.33, 95%CI = 21.32 ~ 212.61；肥胖：OR = 249.99, 95%CI = 79.51 ~ 785.98）。北京市超重或肥胖儿童met相关成分的患病率已达到较高水平。代谢紊乱和肥胖之间有很强的联系。
Data about metabolic syndrome (MetS) in children is limited in China. We aimed to assess the prevalence of MetS related components, and their association with obesity. Data were collected as part of a representative study on MetS among 19593 children, aged 6–18 years old in Beijing. General obesity was assessed by body mass index (BMI) and central obesity by waist circumference. Finger capillary blood tests were used to assess triglyceride (TG), total cholesterol (TC) and impaired fasting glucose (IFG). Vein blood samples were collected from a subsample of 3814 children aged 10–18 years to classify MetS. MetS was defined according to the International Diabetes Federation 2007 definition. The associations between MetS related components and the degree and type of obesity were tested using logistic regression models. The prevalence of overweight, obesity, high blood pressure, elevated TG, TC and IFG were13.6%, 5.8%, 8.5%, 8.8%, 1.2% and 2.5%, respectively. Compared with normal weight children, overweight and obese children were more likely to have other MetS related components. In the subsample of 3814 children aged 10–18 years, the prevalence of MetS was much higher in obese subjects than in their normal weight counterparts (27.6% vs. 0.2%). Children with both general and central obesity had the highest prevalence of MetS. Compared with normal weight children, overweight and obese children were more likely to have MetS (overweight: OR = 67.33, 95%CI = 21.32–212.61; obesity: OR = 249.99, 95% CI = 79.51–785.98). Prevalence of MetS related components has reached high level among Beijing children who were overweight or obese. The association between metabolic disorders and obesity was strong.