Gastrointestinal viruses were not found as an aetiology of culture-negative illness in NICU patients.
Gastrointestinal viruses were not found as an aetiology of culture-negative illness in NICU patients.
复制标题
未发现胃肠道病毒是 NICU 患者培养阴性疾病的病因。
DOI：
10.1136/archdischild-2013-303807
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Tarr,PhillipI
中科院分区：
文献类型：
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作者：
Melamed,Rimma;Storch,GregoryA;Warner,BarbaraB;Tarr,PhillipI
血流感染是早产儿和低出生体重儿死亡和发病的重要原因;由于非特异性表现，通常在该年龄组进行“排除败血症”评估。评估后，给予广谱抗生素，同时等待产率不超过25%-27%的细菌培养结果。1 2新生儿重症监护病房（NICU）中败血症样综合征的病毒原因尚未充分探索，特别是在PCR时代。由于绝大多数脓毒症败血症发作不能产生细菌病原体，我们假设极低出生体重NICU患者的培养阴性败血症发作可能有病毒来源。
Bloodstream infections are a significant cause of mortality and morbidity in premature and low-birth-weight infants; due to non-specific manifestations,‘rule out sepsis’ evaluations are commonly performed in the age group. After evaluation, broad spectrum antibiotics are administered while awaiting the results of bacterial cultures that have a yield of not more than 25%–27%. 1 2Viral causes of sepsis-like syndromes in the neonatal intensive care unit (NICU) have been underexplored, especially in the PCR era. Because a large majority of putatively septic episodes fail to yield a bacterial pathogen, we hypothesised that culture-negative septic episodes in very low-birth-weight NICU patients might have a viral origin.