Estimates of repolarization dispersion from electrocardiographic measurements
Estimates of repolarization dispersion from electrocardiographic measurements
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DOI：
10.1161/01.cir.102.6.685
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发表时间：
2000-08-08
期刊：
影响因子：
37.8
通讯作者：
Lux, RL
中科院分区：
文献类型：
--
作者：
Fuller, MS;Sándor, G;Lux, RL
背景-复极离散度(RD)经常被认为是心脏异常的预测指标。我们提出了一种新的基于心电导联均方根(RMS)曲线的RD测量方法，并与常用的QT离散度(QTd)测量方法进行了比较。方法和结果：利用悬挂在躯干状电解槽中的离体犬心脏，同时记录心外膜部位的电信号和192个“体表”部位的ECG。RMS曲线来自4组导联：心外膜导联、体表导联、胸前导联和6导联最佳导联。通过改变周期长度、温度和激活顺序来改变复极化。根据心外膜电位的恢复时间直接计算RD，并与RMS曲线的T波宽度和QTd进行比较。每组导联T波宽度与RD的相关性分别为：心外膜0.91；体表0.84；胸前0.72；最佳导联0.81。每组导联QTd与RD的相关系数分别为：心外膜0.46，体表0.47，胸前0.17，最佳导联0.11。结论均方根曲线分析提供了一种准确估计体表RD的方法。相比之下，QTd分析提供了一个很差的RD估计。
Background-Repolarization dispersion (Rd) is frequently mentioned as a predictor of cardiac abnormalities. We present a new measure of Rd based on the root-mean-square (RMS) curve of an ECG lead set and compare its performance with that of the commonly used QT dispersion (QTd) measure with the use of recovery times measured from directly recorded canine electrograms.Methods ann Results-Using isolated, perfused canine hearts suspended in a torso-shaped electrolytic tank, we simultaneously recorded electrograms from 64 epicardial sites and ECGs from 192 "body surface" sites. RMS curves were derived from 4 lead sets: epicardial, body surface, precordial, and a 6-lead optimal set. Repolarization was altered by changing cycle length, temperature, and activation sequence. Rd, calculated directly from recovery times of the 64 epicardial potentials, was then compared with the width of the T wave of the RMS curve and with QTd for each of these 4 lend sets. The correlation between T-wave width and Rd for each lead set, respectively, was epicardium, 0.91; body surface, 0.84; precordial, 0.72; and optimal leads, 0.81. The correlation between QTd and Rd for each lead set was epicardium, 0.46; body surface, 0.47; precordial, 0.17; and optimal leads, 0.11.Conclusions-RMS curve analysis provides an accurate method of estimating Rd from the body surface. Ln contrast, QTd analysis provides a poor estimate of Rd.