Liver grafts can be preserved overnight.
Liver grafts can be preserved overnight.
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肝移植物可以保存过夜。
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
K. Boudjema
中科院分区：
文献类型：
--
作者：
J. Vix;P. Compagnon;J. Beller;D. Jaeck;P. Wolf;K. Boudjema
威斯康星州大学方案的引入使肝移植成为半选择性手术。然而，许多研究表明，冷藏不得超过12小时，以避免缺血型胆道并发症，以减少原发性无功能的发生率，并提高移植物和患者的生存。本研究的目的是比较肝脏切取后尽快移植和保存过夜的肝脏的功能。在42个月的时间里，我们研究了133例择期原位肝移植手术。下午6点后开始冷缺血时，第二天早晨进行移植（A组），其余患者立即进行移植（B组）。A组和B组冷缺血时间分别为13.7小时和9.5小时（P <0.001）。两组在初始和晚期生化肝功能、原发性无功能发生率（A组6.5%，B组6.8%）、急性排斥反应发生率（A组45.6%，B组45.7%）以及血管和感染并发症方面具有可比性。未观察到缺血型胆道并发症。两组的移植物和患者存活率相似（A组和B组分别为72.4% vs75.4%和72.9% vs75.8%）。这些结果表明，以下午6点为截止时间，将各组分为连续接受移植的组和推迟到早晨接受移植的组，两组之间在储存方面的差异相对较小。选择性肝移植可以在移植物过夜储存后进行，而不会增加短期或长期的发病率或死亡率。
The introduction of University of Wisconsin solution has made liver transplantation a semi-elective procedure. However, many studies have suggested that cold storage must not exceed 12 hours to avoid ischemic-type biliary complications, to reduce the incidence of primary nonfunction and to improve graft and patient survival. The aim of this study was to compare the function of livers transplanted as soon as possible after the liver was harvested and those preserved overnight. Over a 42-month period, we studied 133 elective orthotopic liver transplantation procedures. When cold ischemia started after 6 PM, patients underwent transplantation the following morning (group A), whereas the remainder underwent transplantation immediately (group B). Cold ischemia lasted 13.7 hours and 9.5 hours in groups A and B, respectively (P < .001). The two groups were comparable in terms of initial and late biochemical liver function, the rates of primary nonfunction (6.5% in group A, 6.8% in group B), acute rejection (45.6% in group A, 45.7% in group B), and vascular and infectious complications. No ischemic-type biliary complications were observed. Graft and patient survival were similar in both groups (72.4% v 75.4% and 72.9% v 75.8% in groups A and B, respectively). These results suggest that having taken a cut off at 6 PM to divide the groups into those that underwent transplantation consecutively and those deferred to the morning, the difference between the two groups in terms of storage is relatively modest. Elective liver transplantation can be performed after overnight graft storage without increasing short-term or long-term morbidity or mortality rates.
犬原位肝移植期间的内源性内毒素血症。
影响因子：
0.9
作者：
Miyata,T;Todo,S;Imventarza,O;Ueda,Y;Furukawa,H;Starzl,TE
通讯作者：
Starzl,TE
内毒素血症和人肝移植。
影响因子：
0.9
作者：
Yokoyama,I;Todo,S;Miyata,T;Selby,R;Tzakis,AG;Starzl,TE
通讯作者：
Starzl,TE