Migraine is associated with enhanced arterial stiffness
Migraine is associated with enhanced arterial stiffness
复制标题
DOI：
10.1291/hypres.30.577
复制
发表时间：
2007-07-01
影响因子：
5.4
通讯作者：
Kohara, Katsuhiko
中科院分区：
文献类型：
--
作者：
Nagai, Tokihisa;Tabara, Yasuharu;Kohara, Katsuhiko
偏头痛是一种常见的头痛亚型。流行病学研究表明，即使在老年人中，偏头痛也可能是缺血性中风的独立危险因素。动脉硬化是脑卒中的主要路径生理基础之一。在本研究中，我们横断面调查偏头痛和动脉僵硬在社区居住的受试者之间可能的关系。研究对象从两个来源独立招募（A组，n=134, 68±5岁；B组，n=138, 68±7岁）。增强指数（AI），即反射压力波的增强压力与脉冲压力的比值，作为动脉刚度的指标。同时测量肱动脉血压。偏头痛的诊断使用先前有效的问卷。偏头痛患病率分别为5.2% （A组）和16.7%（13组）。偏头痛患者在A组（偏头痛，101 +/- 15%；其他头痛，88 +/- 12%；无头痛，86 +/- 12%,p=0.003）和B组（95 +/- 11%,90 +/- 11%,91 +/- 14%,p=0.058）均有较高的径向Al。多元线性回归分析显示，在校正其他混杂因素后，偏头痛是Al的独立决定因素（ss=0.154, p=0.002）：年龄（ss=-0.024, p=0.654）；性别（ss=0.141, p=0.069）；身高（ss=-0.215, p=0.005）；收缩压（ss=0.174, p=0.001）；高血压、高脂血症和糖尿病的药物治疗（ss=-0.014, p=0.787）；心率（ss=-0.539, p < 0.001）。在另一项性别分析中，偏头痛也是Al的重要决定因素（男性，ss=0.246, p=0.019；女性，ss=0.159, p=0.008）。老年偏头痛可能是动脉硬化增强的临床表现。
Migraine is a common subtype of headache. Epidemiological studies have revealed that migraine could be an independent risk factor for ischemic stroke even in elderly subjects. Arterial stiffness is one of the major path ophysiological bases of stroke. In the present study, we cross-sectionally investigated the possible relationship between migraine and arterial stiffness in community-dwelling subjects. The study subjects were independently recruited from two sources (Group A, n=134, 68 +/- 5 years; Group B, n=138, 68 7 years). Augmentation index (AI), the ratio of augmented pressure by the reflection pressure wave to the pulse pressure, was obtained from the radial arterial waveform as an index of arterial stiffness. Brachial blood pressure was also measured simultaneously. Migraine was diagnosed using a previously validated questionnaire. The prevalence of migraine was 5.2% (Group A) and 16.7% (Group 13). Subjects with migraine had higher radial Al in both Group A (migraine, 101 +/- 15%; other headache, 88 +/- 12%; no headache, 86 +/- 12%, p=0.003) and Group B (95 +/- 11%, 90 +/- 11%, 91 +/- 14%, p=0.058). Multiple linear regression analysis revealed that migraine was an independent determinant of Al (ss=0.154, p=0.002) after adjustment for other confounding factors: age (ss=-0.024, p=0.654); sex (ss=0.141, p=0.069); body height (ss=-0.215, p=0.005); systolic blood pressure (ss=0.174, p=0.001); medication for hypertension, hyperlipidemia, and diabetes mellitus (ss=-0.014, p=0.787); and heart rate (ss=-0.539, p < 0.001). In a separate analysis by sex, migraine was also a significant determinant for Al (male, ss=0.246, p=0.019; female, ss=0.159, p=0.008). Migraine in the elderly could be a clinical manifestation of enhanced arterial stiffness.