Elevated interleukin-6 in the cerebrospinal fluid of a previously delineated schizophrenia subtype
Elevated interleukin-6 in the cerebrospinal fluid of a previously delineated schizophrenia subtype
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DOI：
10.1038/sj.npp.1300217
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发表时间：
2003-08-01
影响因子：
7.6
通讯作者：
Holcomb, JA
中科院分区：
文献类型：
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作者：
Garver, DL;Tamas, RL;Holcomb, JA
偶尔有证据表明，精神分裂症患者有免疫激活的迹象，但并非始终如一。对血清中细胞因子异常的研究，偶尔在脑脊液中，产生了不一致的结果，这已经很难解决了。在这样的研究中，精神分裂症被认为是由一个单一的过程组成的，而不是一组障碍。本研究评估了两种精神分裂症患者(延迟反应者(DR)(n=23)和不良反应者(PR)(n=8))在非抗精神病药物加重期间脑脊液(CSF)中促炎症细胞因子IL-6的差异，并与正常对照组(n=14)进行比较。根据随后的治疗反应(在系统治疗6个月期间SAPS评分较基线下降大于/小于60%)，将两种反应亚型分开。IL-6是一种夹心酶联免疫吸附试验，能灵敏、可靠地检测所有受试者脑脊液中的IL-6水平。DR组脑脊液IL-6水平显著高于PR组(P=0.017)和对照组(P=0.013)。除了支持精神分裂症异质性的概念外，这项研究还提供了证据，表明中枢免疫过程可能在精神分裂症的一个亚型中集中发生。
Evidence of immune activation has occasionally, but not consistently, been reported in schizophrenia. Investigations of cytokine abnormalities in serum, and occasionally in CSF, have yielded inconsistent results, which have been difficult to resolve. In such studies, schizophrenia has been assumed to consist of a single process rather than a group of disorders. This study assesses differences in the proinflammatory cytokine, interleukin-6 (IL-6) in the cerebrospinal fluid (CSF) in two previously delineated subtypes of schizophrenics ('delayed-responders' (DR) (n = 23) and 'poor-responders' (PR) (n = 8)) during periods of neuroleptic-free psychotic exacerbation, and in a comparison group of normal controls (n = 14). The two response subtypes were separated by subsequent treatment response (greater/less than 60% reduction of SAPS scores from baseline during 6 months of systematic treatment). The IL-6 assay, a sandwich enzyme-linked immunosorbent assay, was sensitive and reliable to detect IL-6 levels in the CSF of all subjects. CSF IL-6 was found to be significantly higher in the DR than the PR (P = 0.017) and the controls (P = 0.013). In addition to supporting the concept of heterogeneity in schizophrenia, this study also provides evidence that a central immune process may be occurring centrally in one subtype of schizophrenia.