Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice.
Quantitative inheritance of volatile pheromones and darcin and their interaction in olfactory preferences of female mice.
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挥发性信息素和达辛的数量遗传及其对雌性小鼠嗅觉偏好的相互作用
DOI：
10.1038/s41598-017-02259-1
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发表时间：
2017-05-18
影响因子：
4.6
通讯作者：
Zhang YH
中科院分区：
文献类型：
--
作者：
Liu YJ;Guo HF;Zhang JX;Zhang YH
本研究利用C57 B1/6（C57）和BALB/c（BALB）两个近交系小鼠及其正反交杂种（BC = BALB × C57 B1; CB = C57 B1 × BALB），研究了雄性小鼠尿中挥发性化合物（UVC）和darcin是如何从父母那里遗传过来的，以及它们如何相互作用来调节雌性小鼠的嗅觉偏好。化学分析显示，C57 BL/6雄性的UVCs与BALB/c雄性的UVCs在数量上是可区分的。在C57小鼠尿液中检测到Darcin，而在BALB小鼠尿液中未检测到Darcin。BC和CB的UVCs和darcin水平介于C57和BALB之间。在行为上，C57雌性动物始终偏好BALB雄性动物尿液，而不是C57或CB雄性动物，尽管BALB尿液中存在痕量的darcin。然而，对BALB尿液的偏好在BALB与BC对的接触二选一测试中消失，并且当将重组darcin添加到BALB雄性尿液中时恢复。我们的研究结果表明，UVCs和darcin在雄性小鼠的数量遗传和相互作用，影响女性的嗅觉偏好。
In this study, we examined how urine-borne volatile compounds (UVCs) and darcin of male mice are inherited from parents and interact to modulate the olfactory preferences of females using two inbred strains of mice, C57Bl/6 (C57) and BALB/c (BALB), and their reciprocal hybrids (BC = BALB♀× C57♂; CB = C57♀ × BALB♂). Chemical analysis revealed that the UVCs of C57BL/6 males were quantitatively distinguishable from those of BALB/c males. Darcin was detected in C57 urine, but not in BALB urine. The levels of UVCs and darcin in both BC and CB were intermediate between those of C57 and BALB. Behaviourally, C57 females consistently preferred BALB male urine over C57 or CB males despite that there are trace amounts of darcin in BALB urine. However, the preference for BALB urine disappeared in contact two-choice tests of BALB vs. BC pairs, and restored when recombinant darcin was added to BALB male urine. Our results suggested that both UVCs and darcin in male mice are quantitatively inherited and interact to affect the olfactory preferences of females.
影响因子：
5.4
作者：
Brennan PA
通讯作者：
Brennan PA