A multipedal DNA walker for amplified detection of tumor exosomes
A multipedal DNA walker for amplified detection of tumor exosomes
复制标题
用于肿瘤外泌体放大检测的多足 DNA 步行器
DOI：
10.1039/d0cc01817a
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发表时间：
2020-05-07
影响因子：
4.9
通讯作者：
Tang, Yuguo
中科院分区：
文献类型：
--
作者：
Miao, Peng;Tang, Yuguo
我们已经制作了一个超灵敏的外泌体生物传感器的基础上，多足DNA步行者的核心目标外泌体。通过引入CD 63适体实现了特异性识别，并且用磁性Fe3O4@Au纳米颗粒获得了容易的分离。以优异的选择性获得低至6/μ L的检测限。
We have fabricated an ultrasensitive exosome biosensor based on a multipedal DNA walker with a core of target exosomes. Specific recognition is achieved by introducing a CD63 aptamer and facile separation is obtained with magnetic Fe3O4@Au nanoparticles. A limit of detection down to 6/mu L is obtained with excellent selectivity.