Repetitive transcranial magnetic stimulation improve tinnitus in normal hearing patients: a double-blind controlled, clinical and neuroimaging outcome study
Repetitive transcranial magnetic stimulation improve tinnitus in normal hearing patients: a double-blind controlled, clinical and neuroimaging outcome study
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DOI：
10.1111/j.1468-1331.2009.02730.x
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发表时间：
2010-01-01
影响因子：
5.1
通讯作者：
Marcolin, M. A.
中科院分区：
文献类型：
--
作者：
Marcondes, R. A.;Sanchez, T. G.;Marcolin, M. A.
背景和目的：耳鸣是一种常见的疾病，很难治疗，有令人信服的证据表明，耳鸣与中枢神经系统的功能改变有关。靶向调节耳鸣相关的皮层活动已被提出作为一种有前途的新的治疗方法。我们的目的是调查立即和长期的影响，低频（1 Hz）重复经颅磁刺激（rTMS）在耳鸣和正常hearing.Methods：使用平行设计，20例患者随机接受积极或安慰剂刺激左颞顶皮层连续5天。治疗结果采用耳鸣障碍量表进行评估。乙基半胱氨酸二聚体单光子发射计算机断层扫描（SPECT）成像前和14天后rTMS。结果：主动rTMS后有显着改善耳鸣评分相比，假rTMS刺激后长达6个月。SPECT测量结果表明，减少后积极rTMS的左颞叶下部的代谢活动。结论：这些结果支持潜在的rTMS作为一种新的治疗工具，用于治疗慢性耳鸣，表现出一个显着减少耳鸣的投诉超过一段时间至少6个月，并显着减少颞叶皮层下部的神经活动，尽管施加在上级颞叶皮层的刺激。
Background and purpose:Tinnitus is a frequent disorder which is very difficult to treat and there is compelling evidence that tinnitus is associated with functional alterations in the central nervous system. Targeted modulation of tinnitus-related cortical activity has been proposed as a promising new treatment approach. We aimed to investigate both immediate and long-term effects of low frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) in patients with tinnitus and normal hearing.Methods:Using a parallel design, 20 patients were randomized to receive either active or placebo stimulation over the left temporoparietal cortex for five consecutive days. Treatment results were assessed by using the Tinnitus Handicap Inventory. Ethyl cysteinate dimmer-single photon emission computed tomography (SPECT) imaging was performed before and 14 days after rTMS.Results:After active rTMS there was significant improvement of the tinnitus score as compared to sham rTMS for up to 6 months after stimulation. SPECT measurements demonstrated a reduction of metabolic activity in the inferior left temporal lobe after active rTMS.Conclusion:These results support the potential of rTMS as a new therapeutic tool for the treatment of chronic tinnitus, by demonstrating a significant reduction of tinnitus complaints over a period of at least 6 months and significant reduction of neural activity in the inferior temporal cortex, despite the stimulation applied on the superior temporal cortex.