Wireless recording from unrestrained monkeys reveals motor goal encoding beyond immediate reach in frontoparietal cortex
Wireless recording from unrestrained monkeys reveals motor goal encoding beyond immediate reach in frontoparietal cortex
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DOI：
10.7554/elife.51322
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发表时间：
2020-05-04
期刊：
影响因子：
7.7
通讯作者：
Gail, Alexander
中科院分区：
文献类型：
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作者：
Berger, Michael;Agha, Naubahar Shahryar;Gail, Alexander
运动认知的系统神经科学关于空间超越立即达到任务的自由，但实验控制的运动。我们提出了一个实验环境（达到笼）和一个多功能的视觉-触觉交互系统（MaCaQuE）调查目标导向的全身运动的无拘无束的猴子。两只恒河猴对笼中灵活定位的目标进行指示行走和到达运动。我们使用无标记运动捕捉跟踪3D多关节手臂和头部运动。尽管不受限制，但运动显示试验间变异性较小。我们无线记录了192个宽带神经信号从三个皮层感觉运动区同时进行。单个单元活动对于不同的前伸和步行前伸运动是有选择性的。在运动规划过程中，步行和到达目标可以从运动前区和顶叶而不是运动皮层活动中解码。Reach笼允许系统级感觉运动神经科学研究，在可配置的3D空间设置中与不受约束的猴子进行全身运动。我们的结论是，灵长类动物的额顶叶网络编码达到目标超越即时达到运动规划。
System neuroscience of motor cognition regarding the space beyond immediate reach mandates free, yet experimentally controlled movements. We present an experimental environment (Reach Cage) and a versatile visuo-haptic interaction system (MaCaQuE) for investigating goal-directed whole-body movements of unrestrained monkeys. Two rhesus monkeys conducted instructed walk-and-reach movements towards targets flexibly positioned in the cage. We tracked 3D multi-joint arm and head movements using markerless motion capture. Movements show small trial-to-trial variability despite being unrestrained. We wirelessly recorded 192 broadband neural signals from three cortical sensorimotor areas simultaneously. Single unit activity is selective for different reach and walk-and-reach movements. Walk-and-reach targets could be decoded from premotor and parietal but not motor cortical activity during movement planning. The Reach Cage allows systems-level sensorimotor neuroscience studies with full-body movements in a configurable 3D spatial setting with unrestrained monkeys. We conclude that the primate frontoparietal network encodes reach goals beyond immediate reach during movement planning.