Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)
Oxidative burst inhibitory and cytotoxic amides and lignans from the stem bark of Fagara heitzii (Rutaceae)
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DOI：
10.1016/j.phytochem.2009.08.007
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发表时间：
2009-07-01
期刊：
影响因子：
3.8
通讯作者：
Sewald, Norbert
中科院分区：
文献类型：
--
作者：
Mbaze, Luc Meva'a;Lado, Jean Alexandre;Sewald, Norbert
从 F. heitzii (Letouzey) 中分离出两种酰胺（heitziamide A 和 heitziamide B）和两种苯乙醇（heitziethanoid A 和 heitziethanoid B）以及 13 种已知化合物。通过光谱分析确定了所有化合物的结构。在化学发光测定中评估了九种化合物的氧化爆发抑制活性和对PC-3前列腺癌细胞的细胞毒性。所有化合物在IC50=2.0-6.5μM范围内对血清调理酵母聚糖激活后的吞噬反应表现出明显的抑制作用，但没有观察到细胞毒性作用（IC50>100μM）。 (C) 2009 Elsevier Ltd. 保留所有权利。
Two amides, heitziamide A and heitziamide B and two phenylethanoids, heitziethanoid A and heitziethanoid B together with thirteen known compounds were isolated from F. heitzii (Letouzey). The structures of all compounds were established by spectroscopic analysis.Nine compounds were evaluated for oxidative burst inhibitory activity in a chemoluminescence assay and for cytotoxicity against PC-3 prostate cancer cells.All compounds exhibited a clear suppressive effect on phagocytosis response upon activation with serum opsonized zymosan at the range of IC50 = 2.0-6.5 mu M, but no cytotoxic effect was observed (IC50 > 100 mu M). (C) 2009 Elsevier Ltd. All rights reserved.