Human milk IgA concentrations during the first year of lactation
Human milk IgA concentrations during the first year of lactation
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DOI：
10.1136/adc.78.3.235
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发表时间：
1998-03-01
影响因子：
5.2
通讯作者：
Thomas, JE
中科院分区：
文献类型：
--
作者：
Weaver, LT;Arthur, HML;Thomas, JE
AIMS-为了测量总伊加的浓度在牛奶中分泌的两个乳房，在整个第一年的哺乳期，在冈比亚的母亲的婴儿在高风险infection.Subjects和方法六十五名妇女和他们的婴儿进行了研究，每月从产后第4至第52周。在哺乳婴儿之前立即通过手动挤压从每个乳房中获得乳汁样品。牛奶的摄入量进行了测量，通过测试称重的婴儿之前和之后的饲料超过12小时的时间内，伊加浓度测定酶联免疫吸附试验。结果，共1590个牛奶样本进行了测量。所有样本的伊加浓度中位数（四分位数间距）为0.708（0.422-1.105）g/l;左乳为0.785（0.458-1.247）g/l，右乳为0.645（0.388-1.011）g/l（p < 0.0001）。随着婴儿年龄的增长，牛奶和伊加的摄入量没有明显的变化，但是两个乳房之间的伊加浓度有密切的一致性，左右乳房的排出量有（（追踪））。母亲年龄与产次、婴儿摄乳量呈显著负相关（P < 0.01）。在旱季（12月至5月）伊加浓度中位数（四分位距）为0.853（0.571-1.254）g/l，显着高于雨季（6月至11月），当时为0.518（0.311-0.909）g/l（p < 0.0001）。结论-持续的伊加分泌可能会保护哺乳婴儿免受微生物感染。
Aims-To measure the concentrations of total IgA in the milk secreted by both breasts, throughout the first year of lactation, in a cohort of Gambian mothers of infants at high risk of infection.Subjects and methods-Sixty five women and their infants were studied monthly from the 4th to 52nd postpartum week. Samples of milk were obtained from each breast by manual expression immediately before the infant was suckled. Milk intakes were measured by test weighing the infants before and after feeds over 12 hour periods; IgA concentrations were determined by enzyme linked immunosorbent assay.Results-A total of 1590 milk samples was measured. The median (interquartile range) concentration of IgA for all samples was 0.708 (0.422-1.105) g/l; that in milk obtained from the left breast was 0.785 (0.458-1.247) g/l, and that in milk obtained from the right breast was 0.645 (0.388-1.011) g/l (p < 0.0001). There was no significant change in milk or IgA intakes with advancing infant age, but there was a close concordance of IgA concentrations between the two breasts, with ((tracking)) of the output of the left and right breasts. There was a significant (p < 0.01) negative correlation between maternal age and parity, and weight of milk ingested by infants. During the dry season (December to May) the median (interquartile range) IgA concentration was significantly higher at 0.853 (0.571-1.254) g/l than during the rainy season (June to November), when it was 0.518 (0.311-0.909) g/l (p < 0.0001).Conclusions-Sustained IgA secretion is likely to protect suckling infants from microbial infection.