Decreased glomerular proteinase activity in the streptozotocin diabetic rat.
Decreased glomerular proteinase activity in the streptozotocin diabetic rat.
复制标题
链脲佐菌素糖尿病大鼠肾小球蛋白酶活性降低。
DOI：
10.1159/000013492
复制
发表时间：
1999
影响因子：
4.2
通讯作者：
Leehey,DJ
中科院分区：
文献类型：
--
作者：
Song,RH;Singh,AK;Leehey,DJ
肾小球蛋白酶活性降低可能导致糖尿病基质积聚。雄性Sprague-Dawley大鼠静脉注射链脲佐菌素（STZ）65 mg/kg，造成糖尿病;年龄匹配的假注射大鼠作为对照。与对照组相比，STZ注射后1个月的糖尿病大鼠肾小球胶原酶和组织蛋白酶B活性显著降低。胰岛素治疗导致胶原酶活性轻微（但不显著）增加，组织蛋白酶B活性正常化。我们的结论是肾小球胶原酶和组织蛋白酶B活性降低是存在于STZ糖尿病。这些改变可能有助于系膜基质的积累。
Decreased glomerular proteinase activity may contribute to matrix accumulation in diabetes. Male Sprague-Dawley rats were rendered diabetic by injection of streptozotocin (STZ) 65 mg/kg i.v.; age-matched, sham-injected rats served as controls. Glomeruli from diabetic rats 1 month after STZ injection demonstrated significant decreases in collagenase and cathepsin B activities compared to control glomeruli. Treatment with insulin resulted in a slight (but not significant) increase in collagenase activity and normalized cathepsin B activity. We conclude that decreased glomerular collagenase and cathepsin B activities are present in STZ diabetes. These alterations may contribute to mesangial matrix accumulation.