Bordetella holmesii isolated from a patient with sickle cell anemia:: analysis and comparison with other Bordetella holmesii isolates
Bordetella holmesii isolated from a patient with sickle cell anemia:: analysis and comparison with other Bordetella holmesii isolates
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DOI：
10.1046/j.1469-0691.2000.00032.x
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发表时间：
2000-03-01
影响因子：
14.2
通讯作者：
Guiso, N
中科院分区：
文献类型：
--
作者：
Njamkepo, E;Delisle, F;Guiso, N
目的分析从1例镰状细胞性贫血患者中分离的霍氏布氏杆菌，并与其他B菌进行比较。holmesii菌株和分离株以及B.扰动和B.支气管败血波氏杆菌是波氏杆菌属的两个典型种。对Holmesii分离株和参考菌株（ATCC 51541）进行了分析，并与B进行了比较。百日咳和B.支气管肺炎，使用来自感染B、百日咳、B.支气管败血症或B。结果分离的B. Holmesii分离物与B的分离物相似。Holmesii参考菌株和其它分离株。B产生的一些蛋白质。Holmesii分离物与由B产生的分离物相似。百日咳和B.支气管败血症，但没有这些蛋白是相似的毒素和粘附素参与的B的致病性。百日咳和B类支气管炎。由B产生的蛋白质的表型多样性。结论B.如在B中那样调节Holmesii蛋白。百日咳杆菌和支气管炎杆菌B，其中B，holmesii菌株表现出不同的时相，或在B中产生的蛋白质。Holmesii是不同的。
Objective To analyze a Boudetella holmesii isolate from a patient with sickle cell anemia and to compare it with other B. holmesii strains and isolates and with strains of B. pertursis and B. bronchiseptica, two well-characterized species of the Bordetella genus.Methods The bacteriological characteristics and proteins produced by the B. holmesii isolate and the reference strain (ATCC 51541) were analyzed and compared with those of B. pertussis and B. bronchistptica using sera from patients infected with B, pertussis, B. bronchiseptica or B. holmesii.Results The bacteriological characteristics of the B. holmesii isolate studied here were similar to those of the B. holmesii reference strain and other isolates. Some of the proteins produced by B. holmesii isolates were similar to those produced by B. pertussis and B. bronchiseptica, but none of these proteins was similar to the toxins and adhesins involved in the pathogenicity of B. pertussis and B, bronchiseptica. The phenotypic diversity of the proteins produced by B. holmesii isolates and the reference strain was striking.Conclusions Our results suggest that either, the expression of B. holmesii proteins is regulated as in B. pertussis and B, bronthiseptica, with the B, holmesii strain exhibiting different phases, or the proteins produced in B. holmesii are different.