Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives.
Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives.
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人类癌症中竞争性内源性 RNA 网络：假设、验证和观点。
DOI：
10.18632/oncotarget.7266
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发表时间：
2016-03-22
期刊：
影响因子：
--
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Yang C;Wu D;Gao L;Liu X;Jin Y;Wang D;Wang T;Li X
非编码RNA占人类转录组的大部分。然而，对大多数非编码物种的功能和调控机制知之甚少。此外，对编码RNA的潜在非编码功能知之甚少。竞争性内源RNA（ceRNA）假说是近年来提出的。该假说描述了所有转录本RNA物种之间由RNA转录本内的miRNA和miRNA识别元件（MRE）介导的潜在通信网络。本文综述了ceRNA假说的发展过程，总结了验证实验，并讨论了该假说在人类癌症研究中的意义和前景。
Non-coding RNAs represent a majority of the human transcriptome. However, less is known about the functions and regulatory mechanisms of most non-coding species. Moreover, little is known about the potential non-coding functions of coding RNAs. The competing endogenous RNAs (ceRNAs) hypothesis is proposed recently. This hypothesis describes potential communication networks among all transcript RNA species mediated by miRNAs and miRNA-recognizing elements (MREs) within RNA transcripts. Here we review the evolution of the ceRNA hypothesis, summarize the validation experiments and discusses the significance and perspectives of this hypothesis in human cancer.