The receptor kinase CORYNE of Arabidopsis transmits the stem cell-limiting signal CLAVATA3 independently of CLAVATA1
The receptor kinase CORYNE of Arabidopsis transmits the stem cell-limiting signal CLAVATA3 independently of CLAVATA1
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DOI：
10.1105/tpc.107.057547
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发表时间：
2008-04-01
期刊：
影响因子：
11.6
通讯作者：
Simon, Ruediger
中科院分区：
文献类型：
--
作者：
Mueller, Ralf;Bleckmann, Andrea;Simon, Ruediger
拟南芥的芽和花生分生组织中的干细胞分泌限制干细胞增殖并促进分化的信号肽clavata3（CLV3）。提出了CLV3信号通路，以包含受体激酶CLV1和受体样蛋白CLV2。我们在这里表明，新型受体激酶Coryne（CRN）和CLV2一起起作用，并与CLV1并行，以感知CLV3信号。 CRN中的突变会导致干细胞增殖，类似于CLV1，CLV2和CLV3突变体。 CRN在植物开发过程中具有额外的功能，包括与CLV2共享的花卉器官开发。 CRN蛋白缺乏明显的细胞外结构域，我们建议CRN和CLV2通过其跨膜结构域相互作用以建立功能受体。
Stem cells in shoot and floral meristems of Arabidopsis thaliana secrete the signaling peptide CLAVATA3 (CLV3) that restricts stem cell proliferation and promotes differentiation. The CLV3 signaling pathway is proposed to comprise the receptor kinase CLV1 and the receptor-like protein CLV2. We show here that the novel receptor kinase CORYNE (CRN) and CLV2 act together, and in parallel with CLV1, to perceive the CLV3 signal. Mutations in CRN cause stem cell proliferation, similar to clv1, clv2, and clv3 mutants. CRN has additional functions during plant development, including floral organ development, that are shared with CLV2. The CRN protein lacks a distinct extracellular domain, and we propose that CRN and CLV2 interact via their transmembrane domains to establish a functional receptor.