A central role for norepinephrine in the modulation of cerebellar learning tasks.
A central role for norepinephrine in the modulation of cerebellar learning tasks.
复制标题
DOI：
10.1177/1534582304270783
复制
发表时间：
2004-06-01
期刊：
影响因子：
--
通讯作者：
Bickford, Paula C
中科院分区：
文献类型：
--
作者：
Cartford, M Claire;Gould, Thomas;Bickford, Paula C
去甲肾上腺素 (NE) 是一种中枢神经系统神经调节剂，可增强其他神经递质（如 γ-氨基丁酸和谷氨酸）的作用。基于 Marr-Albus 理论，吉尔伯特认为 NE 影响小脑学习的巩固。 NE 耗竭或突触后去甲肾上腺素能受体的阻断会降低一些小脑依赖性学习任务的学习率。小脑β-肾上腺素能受体功能的丧失与相关学习任务的功能丧失相关。改善β-肾上腺素能受体功能的干预措施也可以提高小脑依赖性学习任务的表现。因此，作者提出 NE 在小脑学习调节中发挥核心作用。
Norepinephrine (NE) is a central nervous system neuromodulator that enhances the actions of other neurotransmitters such as gamma-aminobutyric acid and glutamate. Based on the Marr-Albus theories, Gilbert suggested that NE influences consolidation of cerebellar learning. NE depletion or blockade of postsynaptic noradrenergic receptors decreases the rate of learning in several cerebellar-dependent learning tasks. Loss of cerebellar beta-adrenergic receptor function correlates with a loss of function in related learning tasks. Interventions that improve beta-adrenergic receptor function also improve performance in cerebellum-dependent learning tasks. Thus, the authors propose that NE has a central role in the modulation of learning within the cerebellum.