COUNTERPOINT: ESTROGEN AND SEX DO NOT SIGNIFICANTLY INFLUENCE POST-EXERCISE INDEXES OF MUSCLE DAMAGE, INFLAMMATION, AND REPAIR
COUNTERPOINT: ESTROGEN AND SEX DO NOT SIGNIFICANTLY INFLUENCE POST-EXERCISE INDEXES OF MUSCLE DAMAGE, INFLAMMATION, AND REPAIR
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DOI：
10.1152/japplphysiol.90848.2008a
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发表时间：
2009-03-01
影响因子：
3.3
通讯作者：
Clarkson, Priscilla M.
中科院分区：
文献类型：
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作者：
Hubal, Monica J.;Clarkson, Priscilla M.
运动诱发性肌肉损伤（EIMD）发生在剧烈的新运动之后，通过组织分析直接评估，并通过肌肉功能障碍、炎症、迟发性肌肉酸痛和循环中肌肉蛋白（如肌酸激酶（CK）、肌红蛋白）水平升高间接表征。修复通常发生在第一次锻炼后的7-14天。基于雌激素水平影响骨骼肌对损伤性运动的反应这一假设，在过去的20年里，关于EIMD和修复中存在性别差异的争论一直存在（14,28）。雌激素水平影响EIMD反应的潜在机制包括雌激素的抗氧化特性及其在运动期间稳定骨骼肌细胞膜的潜力。与男性相比，这些机制中的任何一种或两种都有助于保护女性免受EIMD的侵害，并促进修复。
Exercise-induced muscle damage (EIMD) occurs following strenuous, novel exercise and is assessed directly via tissue analysis and characterized indirectly by muscle dysfunction, inflammation, delayed onset muscle soreness, and increased levels of muscle proteins [eg, creatine kinase (CK), myoglobin] in circulation. Repair typically takes place during the 7–14 days following the initial exercise bout.There has been much debate over the past 20 years concerning the existence of sex differences in EIMD and repair predicated on the assumption that estrogen levels affect skeletal muscle’s response to damaging exercise (14, 28). Potential mechanisms by which estrogen levels could affect the EIMD response include estrogen’s antioxidant properties and its potential to stabilize the membrane of the skeletal muscle cells during exercise. Either or both of these mechanisms would serve to protect females from EIMD and promote repair when compared with males.