Action, time and the basal ganglia.
Action, time and the basal ganglia.
复制标题
动作、时间和基底神经节。
DOI：
10.1098/rstb.2012.0473
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Yin,HenryH
中科院分区：
文献类型：
--
作者：
Yin,HenryH
在涉及基底神经节的神经系统疾病中，控制运动速度的能力会受到损害，基底神经节是一组皮质下的大脑核团，从中脑接受突出的多巴胺能投射。例如，运动迟缓，运动缓慢，是帕金森氏病的主要症状，而在图雷特综合征患者中观察到快速抽搐。最近的实验工作也涉及多巴胺（DA）和基底神经节的行动时间。在这里，我提出的假设，基底神经节控制的动觉知觉变量的变化率。特别地，感觉运动皮质基底神经节网络实现用于控制运动速度的反馈电路。通过调制该网络中的活动，DA可以改变速度参考信号的增益。因此，DA的缺乏减少了指定身体构型变化率的速度控制系统的输出，减慢了从一种身体构型到另一种身体构型的过渡。
The ability to control the speed of movement is compromised in neurological disorders involving the basal ganglia, a set of subcortical cerebral nuclei that receive prominent dopaminergic projections from the midbrain. For example, bradykinesia, slowness of movement, is a major symptom of Parkinson's disease, whereas rapid tics are observed in patients with Tourette syndrome. Recent experimental work has also implicated dopamine (DA) and the basal ganglia in action timing. Here, I advance the hypothesis that the basal ganglia control the rate of change in kinaesthetic perceptual variables. In particular, the sensorimotor cortico-basal ganglia network implements a feedback circuit for the control of movement velocity. By modulating activity in this network, DA can change the gain of velocity reference signals. The lack of DA thus reduces the output of the velocity control system which specifies the rate of change in body configurations, slowing the transition from one body configuration to another.