Correlation Between Angle Parameters and Central Corneal Thickness in Fuchs Endothelial Corneal Dystrophy
Correlation Between Angle Parameters and Central Corneal Thickness in Fuchs Endothelial Corneal Dystrophy
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福克斯内皮性角膜营养不良的角度参数与中央角膜厚度的相关性
DOI：
10.1097/ico.0000000000002220
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发表时间：
2020
期刊：
影响因子：
2.8
通讯作者：
Nishida Kohji
中科院分区：
文献类型：
--
作者：
Watanabe Shinya;Oie Yoshinori;Miki Atsuya;Soma Takeshi;Koh Shizuka;Kawasaki Satoshi;Tsujikawa Motokazu;Jhanji Vishal;Nishida Kohji
目的：应用眼前段光学相干断层扫描技术，评价Fuchs内皮性角膜营养不良患者(FECD)前房参数与中央角膜厚度(CCT)和周边角膜厚度(PCT)的相关性。方法：病例对照研究包括FECD患者20眼和健康角膜患者31眼。测量CCT作为FECD严重程度的指标。测量前房角参数，包括小梁虹膜角度(TIA500)和房角开放距离(AOD500)，作为周边前房形态的指标。并对PCT和LV进行了分析。结果：FECD患者的CCT(593.9±54.6μm比533.0±25.4μm，P<；0.001)、TIA500(21.8±9.9vs.32.5±11.2°，P=0.002)、LV(0.60±0.27vs.0.40±0.29 mm，P=0.002)均大于对照组。在FECD患者中，CCT与角度参数TIA500(R2=0.29，P=0.009)和AOD500(R2=0.19，P=0.03)呈负相关。PCT与TIA500(R2=0.008，P=0.29)或AOD500(R2=0.007，P=0.29)无显著相关性。CCT与LV无显著相关性(R2=0.02，P=0.55)。结论：CCT越大，前房角宽度越窄，但与LV无相关性。我们发现FECD的严重程度与房角形态有关。
Purpose:To evaluate the correlation between anterior chamber parameters and central corneal thickness (CCT) or peripheral corneal thickness (PCT) in patients with Fuchs endothelial corneal dystrophy (FECD) using anterior segment optical coherence tomography.Methods:This case–control study included 20 eyes from 20 patients with FECD and 31 eyes from 31 patients with healthy corneas. CCT was measured as an indicator of FECD severity. Anterior chamber angle parameters, including trabecular–iris angle (TIA500) and angle opening distance (AOD500), were measured as an indicator of peripheral anterior chamber morphology. We also analyzed PCT and lens vault (LV). The relationships between CCT or PCT and anterior chamber parameters were also analyzed in patients with FECD.Results:Patients with FECD had a larger CCT (593.9±54.6 μm vs. 533.0±25.4 μm, P< 0.001), smaller TIA500 (21.8±9.9 vs. 32.5±11.2 degrees, P= 0.002), smaller AOD500 (0.21±0.11 vs. 0.34±0.18 mm, P= 0.002), and greater LV (0.60±0.27 vs. 0.40±0.29 mm, P= 0.02) than control subjects. In patients with FECD, CCT was negatively correlated with the angle parameters TIA500 (R 2= 0.29, P= 0.009) and AOD500 (R 2= 0.19, P= 0.03). There were no significant correlations between PCT and TIA500 (R 2= 0.008, P= 0.29) or AOD500 (R 2= 0.007, P= 0.29). There were also no significant correlations between CCT and LV (R 2= 0.02, P= 0.55).Conclusions:Larger CCT was significantly associated with narrower anterior chamber angle width, but not with LV. We showed that the severity of FECD is associated with angle chamber morphology.