THE EFFECTS OF MEASUREMENT ERRORS IN THE PLASMA RADIOACTIVITY CURVE ON PARAMETER-ESTIMATION IN POSITRON EMISSION TOMOGRAPHY
THE EFFECTS OF MEASUREMENT ERRORS IN THE PLASMA RADIOACTIVITY CURVE ON PARAMETER-ESTIMATION IN POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1088/0031-9155/36/9/003
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发表时间：
1991-09-01
影响因子：
3.5
通讯作者：
YU, DC
中科院分区：
文献类型：
--
作者：
CHEN, K;HUANG, SC;YU, DC
通过计算机模拟研究了等离子体曲线测量中的三种误差源对正电子发射断层扫描（PET）氟脱氧葡萄糖（FDG）动力学分析中参数估计的影响。 三个误差源是：（1）血浆样本放射性浓度的测量噪声;（2）血浆时间活性曲线相邻血浆采样点之间的线性插值;（3）最小二乘回归使用的权重不正确。 所有这三个误差源被发现增加了参数估计的变异性，第一个是正常PET FDG研究中的主要误差源。 五个估计方法的误差源的性能进行了评估。 当等离子体和组织测量的噪声方差是未知的，迭代加权过程示出，以给出准确和可靠的估计。
The effects of three error sources in plasma curve measurements on parameter estimation in kinetic analysis of positron emission tomography (PET) fluorodeoxyglucose (FDG) data are investigated by computer simulation. The three error sources are: (1) measurement noise in the radioactivity concentrations of plasma samples; (2) linear interpolation between adjacent plasma sampling points of the plasma time activity curve; and (3) incorrect weights used for the least-squares regression. All three error sources are found to increase the variability of the parameter estimates, with the first one a primary error source in normal PET FDG studies. The performance of five estimation methods which account for the error sources are evaluated. When the noise variances of the plasma and the tissue measurements are not known, an iterative weighting procedure is shown to give accurate and reliable estimates.