A pair of novel bisindole alkaloid enantiomers from marine fungus Fusarium sp. XBB-9
A pair of novel bisindole alkaloid enantiomers from marine fungus Fusarium sp. XBB-9
复制标题
来自海洋真菌镰孢菌的一对新型双吲哚生物碱对映体。
DOI：
10.1080/14786419.2019.1655416
复制
发表时间：
2019-08-21
影响因子：
2.2
通讯作者：
Lan, Wen-Jian
中科院分区：
文献类型：
--
作者：
Shaker, Sharpkate;Fan, Run-Zhu;Lan, Wen-Jian
对海洋真菌Fusarium sp. XBB-9进行了初步研究，得到了一对新的双吲哚生物碱对映体（+）-和（-）-fusaspoid A（1a/1b）及12个不同的化合物。一株多化合物（OSMAC）的方法，以提高尽可能多的生物合成途径。化合物的结构经波谱分析确定，1a的绝对构型经X-射线单晶衍射分析确定。测试化合物1a和1b对HCT-15、RKO细胞系的细胞毒活性，但无活性。化合物1a和1b是首次从真菌镰刀菌XBB-9中分离得到的双吲哚生物碱。
A preliminary research on the marine fungus Fusarium sp. XBB-9 resulted in a pair of novel bisindole alkaloid enantiomers, (+)- and (-)-fusaspoid A (1a/1b) and 12 diverse compounds. One strain many compound (OSMAC) method was used to enhance as many biosynthetic pathways as possible. The structures of the compounds were elucidated by spectroscopic analysis, and the absolute configuration of 1a was determined by X-ray single-crystal diffraction analysis. Compounds 1a and 1b were tested for cytotoxic activity against HCT-15, RKO cell lines, but were inactive. Compounds 1a and 1b were the first example of bisindole alkaloids isolated from fungus Fusarium sp. XBB-9.