Epidemiology of Invasive Fungal Disease in Children
Epidemiology of Invasive Fungal Disease in Children
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DOI：
10.1093/jpids/pix046
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发表时间：
2017-09-01
影响因子：
3.2
通讯作者：
Zaoutis, Theoklis
中科院分区：
文献类型：
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作者：
Pana, Zoi Dorothea;Roilides, Emmanuel;Zaoutis, Theoklis
在儿童侵袭性真菌病（IFD）的预防、诊断和管理方面取得了相当大的进展。据报道，在过去15年中，新生儿和儿童侵袭性念珠菌病（IC）的发病率呈下降趋势，这令人鼓舞。然而，由于越来越多的免疫功能低下的儿童面临患IFD的风险，这种疾病仍然与显著的发病率和死亡率有关，并增加了卫生保健系统的经济负担。因此，了解IFD的当代流行病学非常重要。儿童IFD的发病率受地理、人口和时间变化的影响。目前正在努力不断记录和更新不同儿科人群中IFD的发病率和种类分布，作为将预防、诊断和治疗资源直接用于最合适的患者亚群的手段。患有血液恶性肿瘤或原发性或继发性免疫缺陷的儿童，接受实体器官或造血干细胞移植的儿童，以及早产儿是发生IFD风险的儿科患者的主要亚群。在这篇综述中，我们关注真菌疾病流行病学，特别强调两种最常见的儿科ifd， IC和侵袭性曲霉病（IA）。
Considerable progress has been made in the prevention, diagnosis, and management of pediatric patients with invasive fungal disease (IFD). The reported decreasing trend in the incidence of invasive candidiasis (IC) over the past 15 years in both neonates and children has been encouraging. Nevertheless, due to the growing number of immunocompromised children at risk for IFD, this disease continues to be associated with significant morbidity and death and with increased financial burden to the health care system. Therefore, it is important to understand the contemporary epidemiology of IFD. Incidence rates of IFD in children are affected by geographical, population, and time variability. There is an ongoing effort to constantly document and update the incidence of IFD and species distribution among different pediatric populations as a means to direct preventative, diagnostic, and therapeutic resources to the most appropriate subset of patients. Children with a hematologic malignancy or a primary or secondary immunodeficiency, those undergoing solid organ or hematopoietic stem cell transplantation, and premature neonates are the major subsets of pediatric patients at risk of developing IFD. In this review, we focus on fungal disease epidemiology with a specific emphasis on the 2 most common pediatric IFDs, IC and invasive aspergillosis (IA).