Glucocorticoid target cells in human outflow pathway: autopsy and surgical specimens.
Glucocorticoid target cells in human outflow pathway: autopsy and surgical specimens.
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发表时间：
1983-12
影响因子：
4.4
通讯作者：
M. Hernandez;E. Wenk;B. Weinstein;P. Abumohor;S. Podos;M. Dunn;A. Southren
中科院分区：
文献类型：
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作者：
M. Hernandez;E. Wenk;B. Weinstein;P. Abumohor;S. Podos;M. Dunn;A. Southren
糖皮质激素的靶细胞发现于手术获得的青光眼（原发性和继发性）和非青光眼解剖眼的小梁切除术标本中。在小梁网细胞、巩膜成纤维细胞以及施莱姆管和流出血管内皮细胞中发现了3h -地塞米松的特异性核定位。糖皮质激素可以通过直接影响这些细胞的代谢来改变流出设施。放射自显影方法适用于研究与房水流出有关的人体组织的小手术标本中糖皮质激素结合的竞争对手。
Target cells for glucocorticoids were found in trabeculectomy specimens obtained surgically from humans with glaucoma (primary and secondary) and from nonglaucomatous autopsy eyes using an autoradiographic technique. Specific nuclear localization of 3H-dexamethasone was found in cells of the trabecular meshwork, scleral fibroblasts, and in the endothelial lining of both Schlemm's canal and the outflow vessels. Glucocorticoids may alter the outflow facility by a direct effect on the metabolism of these cells. The autoradiographic method is suitable for studying competitors of glucocorticoid binding in small surgical specimens of human tissue involved in the outflow of aqueous humor.