Resetting the Epigenome beyond Pluripotency in the Germline
Resetting the Epigenome beyond Pluripotency in the Germline
复制标题
DOI：
10.1016/j.stem.2009.05.007
复制
发表时间：
2009-06-05
期刊：
影响因子：
23.9
通讯作者：
Surani, M. Azim
中科院分区：
文献类型：
--
作者：
Hayashi, Katsuhiko;Surani, M. Azim
生殖细胞经历全面的表观遗传重编程，以获得多能性和全能性的适应性。值得注意的是，生殖细胞经历的表观遗传重编程的全部程度仍然无法与实验恢复体细胞多能性的尝试相匹配。我们提出，在实验产生的细胞中存在的缺陷在分化成生殖细胞谱系时得到纠正，正如在生殖系传播的情况下所观察到的那样。解开生殖细胞特异性表观遗传重编程的机制可能对基础和临床干细胞研究都有重要意义。
Germ cells undergo comprehensive epigenetic reprogramming toward acquiring fitness for pluripotency and totipotency. Notably, the full extent of the epigenetic reprogramming experienced by germ cells remains unmatched by attempts to experimentally restore pluripotency in somatic cells. We propose that the defects present in experimentally generated cells are corrected upon differentiation into the germ cell lineage, as has been observed in cases of germline transmission. Unraveling the mechanisms responsible for germ cell-specific epigenetic reprogramming will likely have important implications for both basic and clinical stem cell research.