NEUROFIBRILLARY TANGLES AND SENILE PLAQUES IN AGED BEARS
NEUROFIBRILLARY TANGLES AND SENILE PLAQUES IN AGED BEARS
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DOI：
10.1097/00005072-198811000-00006
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发表时间：
1988-11-01
影响因子：
3.2
通讯作者：
PRICE, DL
中科院分区：
文献类型：
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作者：
CORK, LC;POWERS, RE;PRICE, DL
在老年人和患有与年龄相关的退行性疾病，特别是阿尔茨海默病（AD）的个体中，神经元发生细胞骨架异常，包括神经原纤维缠结（NFT）和老年斑（SP）。老年斑发生在几种非人类物种中；然而，在其他哺乳动物中尚未发现与人类具有超微结构或免疫细胞化学相似性的NFT。在这项对5只老年熊（熊，20-30岁）的研究中，我们发现了与人类相似的细胞骨骼异常。一只年老的亚洲棕熊的NFT由10-16纳米的直纤维丝组成，该纤维丝对针对磷酸化的神经纤维丝表位（NF）的抗体具有免疫反应性；τ;A68（一种富含AD的蛋白）；以及与成对螺旋丝（PHF）相关的抗原。一只年老的北极熊有许多SP；这些斑块的神经突对抗NF磷酸化表位的抗体有免疫反应，但未发现NFT。这些结果表明，非灵长类动物也会出现与年龄相关的细胞骨骼异常，类似于人类。老年哺乳动物的比较病理学研究可能有助于阐明这些异常的发病机制。
In aged human beings and in individuals with age-associated degenerative disorders, particularly Alzheimer''s disease (AD), neurons develop cytoskeletal abnormalities, including neurofibrillary tangles (NFT) and senile plaques (SP). Senile plaques occur in several nonhuman species; however, NFT, with ultrastructural or immunocytochemical similarities to those occurring in humans, have not been identified in other mammals. In this study of five aged bears (Ursus, 20-30 years of age), we identified cytoskeletal abnormalities similar to those occurring in humans. An aged Asiatic brown bear had NFT, composed of straight 10-16-nm filaments, that were immunoreactive with antibodies directed against: phosphorylated epitopes of neurofilaments (NF); tau; A68 (a protein enriched in AD); and an antigen associated with paired helical filaments (PHF). An aged polar bear had numerous SP; neurites of these plaques were immunoreactive with antibodies against phosphorylated epitopes of NF, but NFT were not identified. These results indicate that nonprimate species develope age-related cytoskeletal abnormalities similar to those occurring in humans. Investigations of the comparative pathology of aged mammals may be useful in elucidating the pathogeneses of these abnormalities.