White matter changes in multiple sclerosis:: correlation of q-space diffusion MRI and 1H MRS
White matter changes in multiple sclerosis:: correlation of q-space diffusion MRI and 1H MRS
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DOI：
10.1016/j.mri.2005.04.008
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发表时间：
2005-07-01
影响因子：
2.5
通讯作者：
Cohen, Y
中科院分区：
文献类型：
--
作者：
Assaf, Y;Chapman, J;Cohen, Y
目的：探讨高b值弥散磁共振脑成像（“q空间”成像）对多发性硬化（MS）的诊断价值。更具体地说，我们的目的是评估这种方法来识别组织损伤的能力，在所谓的正常出现的白色物质（NAWM）。设计：在这项研究中，我们研究了q-空间扩散成像和磁共振波谱（MRS）为基础的二维H-1化学位移成像之间的相关性。在1.5 T磁共振成像（MRI）扫描仪中扫描8例不同疾病严重程度的MS患者和7例健康受试者。MRI方案包括扩散张量成像（DTI）（B（max）为1000 S/mm（2））、高b值扩散加权成像（B（max）为14，000 S/mm（2））和2D化学位移成像。高b值数据集进行了分析，使用q-空间的方法来产生明显的位移和概率maps.Results：我们发现，CL-空间扩散位移和概率图像强度相关以及N-乙酰天冬氨酸水平（r = 0.61和0.54，分别）。此外，在MRS上异常的NAWM也被发现异常使用q空间扩散成像。在这些区域，q空间位移值从3.8 ± 0.2增加到4.6 ± 0.6 pm（P
Objective: To explore the diagnostic usefulness of high b-value diffusion magnetic resonance brain imaging ("q-space" imaging) in multiple sclerosis (MS). More specifically, we aimed at evaluating the ability of this methodology to identify tissue damage in the so-called normal-appearing white matter (NAWM).Design: In this study we examined the correlation between q-space diffusion imaging and magnetic resonance spectroscopy (MRS)-based two-dimensional H-1 chemical shift imaging. Eight MS patients with different degree of disease severity and seven healthy subjects were scanned in a 1.5-T magnetic resonance imaging (MRI) scanner. The MRI protocol included diffusion tensor imaging (DTI) (with b(max) of 1000 S/mm(2)), high b-value diffusion-weighted imaging (with b(max) of 14,000 s/mm(2)) and 2D chemical shift imaging. The high b-value data set was analyzed using the q-space methodology to produce apparent displacement and probability maps.Results: We found that the cl-space diffusion displacement and probability image intensities correlated well with N-acetylaspartate levels (r = .61 and .54, respectively). Furthermore, NAWM that was abnormal on MRS was also found to be abnormal using q-space diffusion imaging. In these areas, the q-space displacement values increased from 3.8 +/- 0.2 to 4.6 +/- 0.6 pm (P