Four-Dimensional Flow Magnetic Resonance Imaging for Assessment of Velocity Magnitudes and Flow Patterns in The Human Carotid Artery Bifurcation: Comparison with Computational Fluid Dynamics
Four-Dimensional Flow Magnetic Resonance Imaging for Assessment of Velocity Magnitudes and Flow Patterns in The Human Carotid Artery Bifurcation: Comparison with Computational Fluid Dynamics
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DOI：
10.3390/diagnostics9040223
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发表时间：
2019-12-01
期刊：
影响因子：
3.6
通讯作者：
Kwak, Hyo Sung
中科院分区：
文献类型：
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作者：
Ngo, Minh Tri;Kim, Chul In;Kwak, Hyo Sung
目的：了解血管系统的血流动力学对于了解和治疗血管病理很重要。本研究旨在评价四维(4D)流动磁共振成像(MRI)和计算流体动力学(CFD)测量的人颈动脉分叉处的血流动力学。方法：采用12例健康志愿者的MRI数据建立三维血管模型，在CFD模拟中采用4D Flow MRI测量的边界条件。我们比较了两种方法测得的颈动脉分叉处的速度和颈动脉的三维速度流线。结果：两种方法测得的分叉面最大和最小速度值具有较好的一致性。然而，在3D血流显示中，通过4D Flow MRI显示的二次流和回流区的质量较差。结论：4D Flow MRI和CFD显示颈动脉分叉处的血流速度值符合较好。然而，在临床使用4D Flow MRI时，应加强对再循环区血流的可视化和对二次血流特征的评估。
Purpose: Knowledge of the hemodynamics in the vascular system is important to understand and treat vascular pathology. The present study aimed to evaluate the hemodynamics in the human carotid artery bifurcation measured by four-dimensional (4D) flow magnetic resonance imaging (MRI) as compared to computational fluid dynamics (CFD). Methods: This protocol used MRI data of 12 healthy volunteers for the 3D vascular models and 4D flow MRI measurements for the boundary conditions in CFD simulation. We compared the velocities measured at the carotid bifurcation and the 3D velocity streamlines of the carotid arteries obtained by these two methods. Results: There was a good agreement for both maximum and minimum velocity values between the 2 methods for velocity magnitude at the bifurcation plane. However, on the 3D blood flow visualization, secondary flows, and recirculation regions are of poorer quality when visualized through the 4D flow MRI. Conclusion: 4D flow MRI and CFD show reasonable agreement in demonstrated velocity magnitudes at the carotid artery bifurcation. However, the visualization of blood flow at the recirculation regions and the assessment of secondary flow characteristics should be enhanced for the use of 4D flow MRI in clinical situations.