Temperature and concentration calibration of aqueous polyvinylpyrrolidone (PVP) solutions for isotropic diffusion MRI phantoms
Temperature and concentration calibration of aqueous polyvinylpyrrolidone (PVP) solutions for isotropic diffusion MRI phantoms
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DOI：
10.1371/journal.pone.0179276
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发表时间：
2017-06-19
期刊：
影响因子：
3.7
通讯作者：
Bach, Michael
中科院分区：
文献类型：
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作者：
Wagner, Friedrich;Laun, Frederik B.;Bach, Michael
为了使用“表观扩散系数”（D-app）作为定量成像参数，必须使用合适的测试流体。在这项研究中，以前提出的聚乙烯吡咯烷酮（PVP）的水溶液进行了检查，并获得温度校准。例如，在20摄氏度的温度下，D-app的范围为1.594（95% CI：1.593，1.595）μ m（2）/ms至0.3326（95% CI：0.3326）μ m（2）/ms。3304，0.3348）μ m（2）/ms，PVP浓度范围为10%（w/w）至50%（w/w），使用K30聚合物长度。发现Dapp的温度依赖性如此之强，以至于疏忽似乎是不可取的。温度依赖性通过指数函数exp（c（2）（T-20 ° C））来模拟，并报告所确定的c（2）值，其可用于温度校准。例如，我们发现30%（w/ w）PVP浓度和K30聚合物长度的值为0.02952 K-1。一般而言，发现PVP水溶液适合于生产容易应用且可靠的D-苹果素。
To use the "apparent diffusion coefficient" (D-app) as a quantitative imaging parameter, wellsuited test fluids are essential. In this study, the previously proposed aqueous solutions of polyvinylpyrrolidone (PVP) were examined and temperature calibrations were obtained. For example, at a temperature of 20 degrees C, D-app ranged from 1.594 (95% CI: 1.593, 1.595) mu m(2)/ms to 0.3326 (95% CI: 0. 3304, 0.3348) mu m(2)/ms for PVP-concentrations ranging from 10% (w/w) to 50% (w/w) using K30 polymer lengths. The temperature dependence of Dapp was found to be so strong that a negligence seems not advisable. The temperature dependence is descriptively modelled by an exponential function exp(c(2) (T-20 degrees C)) and the determined c(2) values are reported, which can be used for temperature calibration. For example, we find the value 0.02952 K-1 for 30% (w/ w) PVP-concentration and K30 polymer length. In general, aqueous PVP solutions were found to be suitable to produce easily applicable and reliable D-app-phantoms.