Correlation of the apparent diffusion coefficient and the creatine level in early ischemic stroke: A comparison of different patterns by magnetic resonance
Correlation of the apparent diffusion coefficient and the creatine level in early ischemic stroke: A comparison of different patterns by magnetic resonance
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DOI：
10.1002/jmri.1048
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发表时间：
2001-03-01
影响因子：
4.4
通讯作者：
Tan, KP
中科院分区：
文献类型：
--
作者：
Rumpel, H;Khoo, JBK;Tan, KP
据报道，中风后表观扩散系数（ADC）的降低可持续数天，之后ADC逐渐增加到异常高的水平。我们评估了脑卒中病变的ADC值，并通过肌酸（Cre）水平将结果与病变的细胞密度进行比较。这种双参数估计在确定潜在的细胞状态方面具有特别的相关性。基于弥散加权回波平面和快速自旋回波成像获得病变对侧ADC比。用单体素定位光谱定量分析梗死区脑代谢物。并与同位对侧区域的水平进行了比较。15例缺血性卒中患者在症状出现后18-88小时内接受检查。在脑卒中病变中，ADC与Cre水平有显著相关性，细胞密度越高，ADC值越低。ADC与病变Cre浓度、病变与对侧Cre比值（Cre.）的相关强度分别为R-2 = 0.70和0.58。结果表明，ADC能较好地反映细胞密度。在细胞结构稳定的情况下，ADC值会大大降低。ADC和Cre水平在脑卒中病变的顺序分期表征中具有互补作用。(C) 2001 Wiley-Liss, Inc。
it has been reported that reduction of the apparent diffusion coefficient (ADC) after stroke can persist for several days, after which the ADC increases gradually to an abnormally high level. We evaluated ADC values of stroke lesions and compared the results to the cellular density of the lesion by means of the creatine (Cre) level. This two-parameter estimation is of particular relevance in ascertaining the underlying cellular status. Lesion-to-contralateral ADC ratios (ADC.) were obtained based on diffusion-weighted echo-planar and fast spin-echo imaging. Single-voxel localized spectroscopy was used for quantification of cerebral metabolites in infarcted regions. Their levels were also compared to that in homotopic contralateral regions. Fifteen patients with ischemic stroke were examined at times ranging from 18-88 hours following the onset of symptoms. In the stroke lesion, there was a significant correlation between the ADC and the Cre level showing that the higher the cell density the lower the ADC value. For ADC, vs. the lesion Cre concentration and the lesion-to-contralateral Cre ratio (Cre.), the strengths of relationship were R-2 = 0.70 and 0.58, respectively. It is concluded that ADC is a good reflection of cell density. Greatly lowered ADC values occur within the context of a stable cellularity. ADC and the Cre level have complementary roles in the characterization of stroke lesion with regard to the sequential stage. (C) 2001 Wiley-Liss, Inc.