Insulin-like growth factor 1 as a predictor of ischemic stroke outcome in the elderly
Insulin-like growth factor 1 as a predictor of ischemic stroke outcome in the elderly
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DOI：
10.1016/j.amjmed.2004.02.049
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发表时间：
2004-09-01
影响因子：
5.9
通讯作者：
Ceda, GP
中科院分区：
文献类型：
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作者：
Denti, L;Annoni, V;Ceda, GP
目的：检查中风发作后早期测定的血清胰岛素样生长因子 1 (IGF-1) 和 IGF 结合蛋白 3 (IGFBP-3) 浓度是否可以预测老年患者的临床结果。 方法：样本包括 85 名入院的患者（平均 [+/-SD] 年龄，83 +/- 7.4 岁；范围，67 至 99 岁；34% 男性）。 1998 年 1 月至 2000 年 6 月间，老年病房的急性中风患者，以及 88 名年龄和性别相似的对照患者。采用临床和实验室评估、头部计算机断层扫描、颈动脉超声检查和心电图来定义临床和病因学中风亚型。入院24小时内采集空腹血样用于IGF-I和IGFBP-3测量。单变量和多重逻辑回归分析，并调整其他相关临床协变量，用于评估 IGF-I 和 IGFBP-3 与不良结果（定义为严重残疾）的关系（Barthel 指数）
PURPOSE: To examine, whether serum insulin-like growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) concentrations, determined early after the onset of stroke, are predictive of clinical outcome in elderly patients.METHODS: The sample comprised 85 patients (mean [+/-SD] age, 83 +/- 7.4 years; range, 67 to 99 years; 34% male) who were admitted with acute stroke to a geriatric ward between January 1998 and June 2000, and 88 control patients who were similar in age and sex. Clinical and laboratory assessments, computed tomographic scan of the head, carotid ultrasonography, and electrocardiography were employed to define the clinical and etiologic stroke subtype. Fasting blood samples were collected within 24 hours of admission for IGF-I and IGFBP-3 measurement. Univariate and multiple logistic regression analyses, with adjustment for other related clinical covariates, were used to assess the relation of IGF-I and IGFBP-3 to poor outcome, defined as severe disability (Barthel index