Fast Setting Silk Fibroin Bioink for Bioprinting of Patient-Specific Memory-Shape Implants
Fast Setting Silk Fibroin Bioink for Bioprinting of Patient-Specific Memory-Shape Implants
复制标题
DOI：
10.1002/adhm.201701021
复制
发表时间：
2017-11-22
影响因子：
10
通讯作者：
Reis, Rui L.
中科院分区：
文献类型：
--
作者：
Costa, Joao B.;Silva-Correia, Joana;Reis, Rui L.
追求“完美”的仿生和个性化的肌肉骨骼组织再生植入物仍然是一个很大的挑战。利用新型和有前途的生物材料的3D打印技术可以成为解决方案的一部分。在这项研究中，开发了一种用于3D生物打印的快速凝固酶交联丝素蛋白（SF）生物墨水。它们的性能是微调和不同的结构具有良好的分辨率，再现性和可靠性可以制造。SF生物墨水存在许多潜在的应用，包括3D生物打印支架和患者特异性植入物，其表现出独特的特性，例如良好的机械性能、记忆形状特征、合适的降解以及可调的孔结构和形态。
The pursuit for the "perfect" biomimetic and personalized implant for musculoskeletal tissue regeneration remains a big challenge. 3D printing technology that makes use of a novel and promising biomaterials can be part of the solution. In this study, a fast setting enzymatic-crosslinked silk fibroin (SF) bioink for 3D bioprinting is developed. Their properties are fine-tuned and different structures with good resolution, reproducibility, and reliability can be fabricated. Many potential applications exist for the SF bioinks including 3D bioprinted scaffolds and patient-specific implants exhibiting unique characteristics such as good mechanical properties, memory-shape feature, suitable degradation, and tunable pore architecture and morphology.