Very Early Identification and Intervention for Infants at Risk of Neurodevelopmental Disorders: A Transdiagnostic Approach
Very Early Identification and Intervention for Infants at Risk of Neurodevelopmental Disorders: A Transdiagnostic Approach
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DOI：
10.1111/cdep.12319
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发表时间：
2019-06-01
影响因子：
6.4
通讯作者：
Downs, Jenny
中科院分区：
文献类型：
--
作者：
Finlay-Jones, Amy;Varcin, Kandice;Downs, Jenny
神经发育障碍(NDDS)在生命的最初几个月就开始了，但许多此类障碍的临床表现--包括智力残疾、自闭症谱系障碍、注意力缺陷多动障碍和胎儿酒精谱系障碍--往往要到很久以后才能看到。从理论上讲，早期干预为优化高危儿童的结局提供了最好的机会。然而，早期干预的机会可能会因为依赖于评估经常在童年后期出现的显性表型或行为症状而受阻。在这篇文章中，我们研究了跨诊断、多维方法对具有NDDS风险的婴儿进行非常早期的识别和干预的效用。我们考虑如何整合流行病学、系统生物学和发育神经科学的见解，以帮助识别高危婴儿并开发有针对性的适应性干预措施。我们还强调了研究的方向。
Neurodevelopmental disorders (NDDs) begin in the earliest months of life, but the clinical manifestations of many such disorders-including intellectual disability, autism spectrum disorder, attention-deficit hyperactivity disorder, and fetal alcohol spectrum disorder-are often not seen until much later. Theoretically, very early intervention provides the best chance for optimizing outcomes for children at risk. However, opportunities for early intervention may be thwarted by a dependence on assessing overt phenotypic or behavioral symptoms that often emerge later in childhood. In this article, we examine the utility of a transdiagnostic, dimensional approach to very early identification and intervention for infants at risk of NDDs. We consider how insights from epidemiology, systems biology, and developmental neuroscience may be integrated to aid identifying at-risk infants and developing targeted, adaptive interventions. We also highlight directions for research.