Electrophysiological studies in Guillain-Barré syndrome: correlation with antibodies to GM1, GD1B and Campylobacter jejuni.
Electrophysiological studies in Guillain-Barré syndrome: correlation with antibodies to GM1, GD1B and Campylobacter jejuni.
复制标题
吉兰-巴利综合征的电生理学研究：与 GM1、GD1B 和空肠弯曲杆菌抗体的相关性。
DOI：
10.1007/bf00873550
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发表时间：
1995
影响因子：
6
通讯作者：
Koski,CL
中科院分区：
文献类型：
--
作者：
Vriesendorp,FJ;Triggs,WJ;Mayer,RF;Koski,CL
对50例格林-巴利综合征（GBS）患者进行了回顾性研究，通过ELISA测定空肠弯曲菌、GM 1和GDlb抗体的存在，对系列运动神经传导研究进行了相关分析。具有C抗体的GBS患者。空肠（n= 8）、GM 1（n= 4）或GD 1b（n= 4）显示出类似于没有这些特异性抗体的GBS患者的电生理学特征，提示脱髓鞘伴延长的远端运动延迟和暂时分散/传导阻滞。50例GBS患者中有3例在症状发作后1年恢复不佳，无法行走。所有三名患者都有C抗体。空肠对GM 1和GD 1 B无影响。虽然后来在临床过程中远端运动反应是不存在的，在这些患者中，反映了广泛的轴突变性，早期神经传导研究结果提示脱髓鞘。我们认为周围神经脱髓鞘可能是GBS的初始发病机制，与抗C抗体的存在无关。空肠、GM 1或GDlb。
A retrospective study of 50 patients with Guillain-Barré syndrome (GBS) correlated analysis of serial motor nerve conduction studies with the presence of antibodies toCampylobacter jejuni, GM 1 and GDlb, determined by ELISA. GBS patients with antibodies toC. jejuni(n= 8), GM1 (n= 4), or GD1b (n= 4) showed electrophysiological features suggestive of demyelination with prolonged distal motor latencies and temporal dispersion/conduction block similar to GBS patients without these specific antibodies. Three of 50 GBS patients had poor recovery with inability to walk at 1 year after onset of symptoms. All three patients had antibodies to C. jejuni, but not to GM 1 or GD 1 b. Although later on in the clinical course distal motor responses were absent in two of these patients, reflecting extensive axonal degeneration, early nerve conduction studies showed findings suggestive of demyelination. We suggest that demyelination of peripheral nerve may be the initial disease mechanism in GBS independent of the presence of antibodies toC. jejuni, GM1 or GDlb.